C12N 2320/50
Methods for regulating/modulating their activity
C12N2320/50 (Methods for regulating/modulating their activity) appears on 918 US grants and 1,681 published applications in this corpus.
Search patents in C12N- Granted patents
- 918
- Published applications
- 1,681
- Assignees
- 494
- Inventors
- 2,048
- Latest grant
- 29 Sep 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1997 | 1 | 0 |
| 1998 | 0 | 0 |
| 1999 | 1 | 0 |
| 2000 | 0 | 0 |
| 2001 | 0 | 0 |
| 2002 | 0 | 1 |
| 2003 | 1 | 10 |
| 2004 | 1 | 27 |
| 2005 | 0 | 45 |
| 2006 | 2 | 41 |
| 2007 | 2 | 53 |
| 2008 | 5 | 37 |
| 2009 | 6 | 88 |
| 2010 | 26 | 83 |
| 2011 | 38 | 66 |
| 2012 | 57 | 65 |
| 2013 | 51 | 57 |
| 2014 | 57 | 77 |
| 2015 | 54 | 115 |
| 2016 | 65 | 96 |
| 2017 | 76 | 86 |
| 2018 | 74 | 91 |
| 2019 | 64 | 86 |
| 2020 | 59 | 78 |
| 2021 | 59 | 95 |
| 2022 | 65 | 94 |
| 2023 | 39 | 101 |
| 2024 | 39 | 81 |
| 2025 | 55 | 68 |
| 2026 | 21 | 40 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Subgroups
Granted patents
Recent patents
- Riboswitch modulated gene therapy for retinal diseases29 Sep 2026US 12,747,441 B2The Medical College of Wisconsin, Inc.
- Modified guide RNAs15 Sep 2026US 12,735,698 B2Intellia Therapeutics, Inc.
- Aptamer nanofibers and kill-switches and uses thereof28 Jul 2026US 12,692,501 B2The Penn State Research Foundation
- Conditional-siRNAs and uses thereof in treating acute myeloid leukemia7 Jul 2026US 12,674,164 B2California Institute of Technology
- Methods and compositions for inhibition of CRISPR re-cleavage events16 Jun 2026US 12,655,422 B2Integrated Dna Technologies, Inc.
- Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof17 Sep 2026US 2026/0273070 A1City of Hope
- Compositions, Methods, And Systems For Targeting And Destabilizing RNA Transcripts (TNBC)3 Sep 2026US 2026/0256824 A1UTR Therapeutics Inc.
- Compositions of Asymmetric Interfering RNA and Uses Thereof3 Sep 2026US 2026/0258412 A11Globe Health Institute LLC
- Modification of small rnas for therapeutic uses3 Sep 2026US 2026/0258415 A1City of Hope
- Formulations of nucleic acid compounds and uses thereof27 Aug 2026US 2026/0248839 A1Comanche Biopharma Corp.
Most cited
By later US patents
- In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom267US 5,624,803 AThe Regents of the University of California · 1997
- Oligonucleotides with alternating segments of locked and non-locked nucleotides183US 7,687,617 B2Santaris Pharma A/S · 2010
- Methods and compositions involving miRNA and miRNA inhibitor molecules171US 9,506,061 B2Asuragen, Inc. · 2016
- Methods and compositions for controlling efficacy of RNA silencing170US 7,459,547 B2University of Massachusetts · 2008
- Modified siRNA molecules and uses thereof167US 8,101,741 B2Protiva Biotherapeutics, Inc. · 2012