A61K 49/223
Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Official title: {Microbubbles, hollow microspheres, free gas bubbles, gas microspheres}
A61K49/223 (Microbubbles, hollow microspheres, free gas bubbles, gas microspheres) appears on 592 US grants and 591 published applications in this corpus.
Search patents in A61K- Granted patents
- 592
- Published applications
- 591
- Assignees
- 263
- Inventors
- 997
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1981 | 2 | 0 |
| 1982 | 0 | 0 |
| 1983 | 0 | 0 |
| 1984 | 2 | 0 |
| 1985 | 0 | 0 |
| 1986 | 1 | 0 |
| 1987 | 3 | 0 |
| 1988 | 2 | 0 |
| 1989 | 2 | 0 |
| 1990 | 1 | 0 |
| 1991 | 0 | 0 |
| 1992 | 6 | 0 |
| 1993 | 8 | 0 |
| 1994 | 13 | 0 |
| 1995 | 13 | 0 |
| 1996 | 43 | 0 |
| 1997 | 35 | 0 |
| 1998 | 42 | 0 |
| 1999 | 23 | 0 |
| 2000 | 42 | 0 |
| 2001 | 31 | 16 |
| 2002 | 20 | 32 |
| 2003 | 31 | 43 |
| 2004 | 12 | 28 |
| 2005 | 11 | 36 |
| 2006 | 16 | 18 |
| 2007 | 6 | 13 |
| 2008 | 6 | 15 |
| 2009 | 3 | 16 |
| 2010 | 6 | 18 |
| 2011 | 5 | 18 |
| 2012 | 9 | 15 |
| 2013 | 7 | 16 |
| 2014 | 10 | 27 |
| 2015 | 13 | 21 |
| 2016 | 15 | 24 |
| 2017 | 18 | 17 |
| 2018 | 13 | 28 |
| 2019 | 22 | 23 |
| 2020 | 14 | 26 |
| 2021 | 16 | 36 |
| 2022 | 18 | 34 |
| 2023 | 13 | 23 |
| 2024 | 17 | 17 |
| 2025 | 13 | 17 |
| 2026 | 9 | 14 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Method and apparatus for measuring intravascular blood flow using a backscattering contrast6 Oct 2026US 12,751,639 B2The General Hospital Corporation
- Syringe-based microbubble generator with an aerator25 Aug 2026US 12,714,779 B2Agitated Solutions Inc.
- Microbubble destruction for medical ultrasound imaging18 Aug 2026US 12,708,347 B2Siemens Medical Solutions USA, Inc.
- Stabilized nanobubbles and microbubbles for diagnostic and therapeutic applications23 Jun 2026US 12,661,414 B2Case Western Reserve University
- Method to induce exfoliation of cells and/or tissue fragments for enhanced cytopathologic cell collection16 Jun 2026US 12,653,509 B2Adenocyte Ltd.
- Gas-filled microvesicles with perfluoro olefin1 Oct 2026US 2026/0295097 A1Bracco Suisse SA
- Compositions and methods of controlling expression of thermogenin (ucp-1) in skeletal muscles10 Sep 2026US 2026/0263560 A1Thermogen Biotherapeutics, LLC
- Substantially Monodisperse Ultrasound Responsive Nanobubble Compositions and Methods of Production and Use Thereof13 Aug 2026US 2026/0232849 A1University of Central Florida Research Foundation, Inc.
- Echogenic Encapsulations6 Aug 2026US 2026/0224757 A1
- Method For Producing Ultrasound-Sensitive Drug Carrier For Delivering Hydrophobic Drug, And Ultrasound-Sensitive Drug Carrier Using Same30 Jul 2026US 2026/0216380 A1BioInfra Life Science Inc.
Most cited
By later US patents
- Biodegradable injectable nanoparticles724US 5,543,158 AMassachusetts Institute of Technology · 1996
- Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously662US 5,558,092 AImaRx Pharmaceutical Corp. · 1996
- Diagnosis, removal, or mechanical damaging of tumor using plasmonic nanobubbles513US 10,471,159 B1Masimo Corporation · 2019
- Therapeutic drug delivery systems498US 5,580,575 AImaRx Pharmaceutical Corp. · 1996
- Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles492US 5,215,680 ACavitation-Control Technology, Inc. · 1993