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US 12,653,509 B2Granted
Method to induce exfoliation of cells and/or tissue fragments for enhanced cytopathologic cell collection
AssigneeAdenocyte Ltd.
InventorsDan Adam, Emmanuel Loeb
Life of this patent
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Abstract
Methods and techniques for obtaining enriched cell samples from an organ in a subject using an ultrasound contrast agent and insonating. Contiguous fragments of epithelia are obtained which are useful for subsequent histological analysis and for informing therapy and other medical considerations.
Claims27
A method of obtaining pancreatic cells from a subject comprising:
- administering an amount of a microbubble containing agent to the subject;
- and
- insonating a pancreas of the subject with an amount of ultrasonic energy effective to elicit stable cavitation and elicit exfoliation of cells into a duct of said pancreas by interaction of said energy with said microbubbles in said subject's pancreas, without creating inertial cavitation in said pancreas.
A method of obtaining pancreatic cells from a subject comprising:
- administering an amount of a contrast bubble agent to the subject;
- and
- insonating a pancreas of the subject with an amount of ultrasonic energy effective to elicit exfoliation of cells into a duct of said pancreas by mechanical interaction of said contrast bubble agent with said subject's pancreas, without creating inertial cavitation in said pancreas.
Dependencies are inferred from the claim text.