A61K 47/6889
Conjugates wherein the antibody being the modifying agent and wherein the linker
Official title: {Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment}
A61K47/6889 (Conjugates wherein the antibody being the modifying agent and wherein the linker) appears on 1,108 US grants and 2,488 published applications in this corpus.
Search patents in A61K- Granted patents
- 1,108
- Published applications
- 2,488
- Assignees
- 725
- Inventors
- 4,740
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1977 | 2 | 0 |
| 1978 | 0 | 0 |
| 1979 | 0 | 0 |
| 1980 | 0 | 0 |
| 1981 | 1 | 0 |
| 1982 | 2 | 0 |
| 1983 | 2 | 0 |
| 1984 | 1 | 0 |
| 1985 | 0 | 0 |
| 1986 | 1 | 0 |
| 1987 | 5 | 0 |
| 1988 | 1 | 0 |
| 1989 | 2 | 0 |
| 1990 | 4 | 0 |
| 1991 | 12 | 0 |
| 1992 | 17 | 0 |
| 1993 | 5 | 0 |
| 1994 | 2 | 0 |
| 1995 | 5 | 0 |
| 1996 | 6 | 0 |
| 1997 | 7 | 0 |
| 1998 | 6 | 0 |
| 1999 | 2 | 0 |
| 2000 | 1 | 0 |
| 2001 | 2 | 1 |
| 2002 | 2 | 4 |
| 2003 | 6 | 9 |
| 2004 | 0 | 7 |
| 2005 | 1 | 9 |
| 2006 | 2 | 5 |
| 2007 | 4 | 9 |
| 2008 | 3 | 18 |
| 2009 | 8 | 8 |
| 2010 | 4 | 14 |
| 2011 | 12 | 11 |
| 2012 | 11 | 27 |
| 2013 | 14 | 24 |
| 2014 | 19 | 52 |
| 2015 | 36 | 67 |
| 2016 | 48 | 109 |
| 2017 | 58 | 123 |
| 2018 | 58 | 104 |
| 2019 | 69 | 147 |
| 2020 | 88 | 121 |
| 2021 | 89 | 176 |
| 2022 | 70 | 187 |
| 2023 | 116 | 260 |
| 2024 | 115 | 352 |
| 2025 | 122 | 347 |
| 2026 | 67 | 297 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Muscle targeting complexes and formulations for treating facioscapulohumeral muscular dystrophy6 Oct 2026US 12,752,013 B2Dyne Therapeutics, Inc.
- Anti-Nectin-4 antibody, conjugate including the same, and application thereof6 Oct 2026US 12,753,230 B2Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
- Antibody-drug conjugates and their uses15 Sep 2026US 12,734,244 B2Mablink Bioscience
- Compounds capable of binding to proteins and conjugates obtained from these compounds8 Sep 2026US 12,728,170 B2Mc Saf
- Stabilized trioxacarcin antibody drug conjugates and uses thereof1 Sep 2026US 12,721,904 B2President and Fellows of Harvard College
- Delivery of dual payload of mmaf or mmae and tlr7 agonists8 Oct 2026US 2026/0306648 A1The Research Foundation for The State University of New York
- Methods for treating patients with locally advanced or metastatic urothelial cancer with antibody drug conjugates (adc) that bind 191p4d12 proteins in combination with pembrolizumab8 Oct 2026US 2026/0306649 A1Agensys, Inc.
- Camptothecin drug conjugate and use thereof8 Oct 2026US 2026/0306650 A1Shanghai Zaimo Biotechnology Co., Ltd.
- Anti-cmet antibody, antibody-drug conjugate, and preparation method therefor and use thereof8 Oct 2026US 2026/0306651 A1MediLink Therapeutics (Suzhou) Co., Ltd.
- Anti-trop2 antibody-drug conjugates comprising pnu-159682 derivatives8 Oct 2026US 2026/0306652 A1Merck Sharp & Dohme Corp.
Most cited
By later US patents
- Lysosomal enzyme-cleavable antitumor drug conjugates653US 6,214,345 B1Bristol-Myers Squibb Company · 2001
- Antibody conjugates for the delivery of compounds to target sites546US 4,671,958 ACytogen Corporation · 1987
- Monomethylvaline compounds capable of conjugation to ligands486US 7,498,298 B2Seattle Genetics, Inc. · 2009
- Cysteine engineered antibodies and conjugates485US 7,521,541 B2Genetech, Inc. · 2009
- Peptide linkers for improved oligonucleotide delivery355US 5,574,142 AMicroProbe, Inc. · 1996