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US 12,734,244 B2Granted
Antibody-drug conjugates and their uses
AssigneeMablink Bioscience
InventorWarren Viricel
Life of this patent
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Abstract
The present invention relates to antibody-drug conjugates, wherein the antibody specifically binds to folate receptor a, and wherein the drug is preferably chosen among a cytotoxic drug. Such antibody-drug conjugates are useful in particular in treating proliferative diseases including cancers, such as ovarian, breast and non-small cell lung cancers.
Claims9
An antibody-drug conjugate of formula (I):
- Ab-[L-D]p (I),
- wherein:
- Ab is an anti-folate receptor alpha (FRα) antibody which binds specifically to the folate receptor alpha of SEQ ID NO:12,
- L is a cleavable linker moiety of formula (VI):
- and L is covalently bonded to one or more thiol residues of said antibody,
- D is the drug moiety of exatecan of formula (II) bonded to L,
- and
- p is from 1 to 8.
5 more elements
An antibody-drug conjugate of formula (VII):
- wherein Ab is an anti-FRα antibody which comprises a variable heavy chain polypeptide comprising VH of SEQ ID NO:7 and a variable light chain polypeptide comprising VL of SEQ ID NO:8, and wherein the IgG1 Fc constant region comprises alanine substitutions in Leucine 234 and Leucine 235, and p is 8.
Dependencies are inferred from the claim text.