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US 12,728,170 B2Granted
Compounds capable of binding to proteins and conjugates obtained from these compounds
AssigneeMc Saf
InventorsLudovic Juen, Camille Gely, Estelle Huet
Life of this patent
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Abstract
The disclosure relates to a compound of formula (I): wherein X, A, Y and X1 are as defined in the description. The disclosure also relates to a conjugate between a protein comprising at least two disulfide bridges and a compound of formula (I).
Claims13
A compound of formula (II):
- wherein:
- the attachment head is a compound of formula (I), formula (Ia), or formula (Ib):
- wherein:
- each A is the residue of a pyridyl;
- each X is a halogen;
- each Y is selected from a direct bond, —CO—, and —NH—;
- X1 is
- W is —CONR3R4 or —NR3COR4;
- each Z is independently a direct bond, —CH2—, —O—, —S—, —CO—, —NH—, or —C(═NR1)—;
- and m, n and p are each, independently of one another, an integer in the range from 0 to 8;
- R3 is —H or —(C1-C6)alkyl or —(CH2)u—SO3H;
- R4 is —(CH2CH2O)qR5, —(CRcRd)rR5, —(CRcRd)r—NHCO—(CH2CH2O)q—R5, —(CRcRd)r—CONH—(CH2CH2O)q—R5, —(CH2CH2O)q—(CH2)r—NHCO—(CRcRd)r—R5, —(CH2CH2O)q—(CH2)r—CONH—(CRcRd)r—R5, —CH—[(CRcRd)r—CONH—(CRcRd)r—(OCH2CH2)q—R5]2, —CH—[(CRcRd)r—NHCO—(CRcRd)r—(OCH2CH2)q—R5]2, —CH—[(CRcRd)r—CONH—(CRcRd)rR5]2, or —CH—[(CRcRd)r—NHCO—(CRcRd)r—R5]2;
- R5 is —(CH2)sR6 or —(CH2)sR7;
- R6 is —COOR8, —COSR8, —CONR8R9, or —NR8COR9;
- R7 is selected from:
- Rc is —H;
- each Rd is —H, —SO3H, or —CH2—SO3H;
- R8 is —H or —(C1-C6)alkyl;
- R9 is —H or —(C1-C6)alkyl;
- each q is an integer in the range from 1 to 24;
- each r is an integer in the range from 1 to 8;
- each s is an integer in the range from 0 to 6;
- each u is an integer in the range from 1 to 6;
- the binding arm is a direct bond;
- an amino acid residue;
- or a peptide residue;
- the spacer is a direct bond or a group of formula:
- M is a molecule of interest.
25 more elements
Dependencies are inferred from the claim text.