A61K 31/4458
Only substituted in position 2
Official title: only substituted in position 2, e.g. methylphenidate
A61K31/4458 (Only substituted in position 2) appears on 481 US grants and 785 published applications in this corpus.
Search patents in A61K- Granted patents
- 481
- Published applications
- 785
- Assignees
- 248
- Inventors
- 653
- Latest grant
- 15 Sep 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1996 | 1 | 0 |
| 1997 | 6 | 0 |
| 1998 | 5 | 0 |
| 1999 | 9 | 0 |
| 2000 | 2 | 0 |
| 2001 | 13 | 2 |
| 2002 | 9 | 13 |
| 2003 | 5 | 19 |
| 2004 | 2 | 9 |
| 2005 | 5 | 15 |
| 2006 | 2 | 14 |
| 2007 | 3 | 6 |
| 2008 | 4 | 9 |
| 2009 | 3 | 20 |
| 2010 | 3 | 17 |
| 2011 | 2 | 22 |
| 2012 | 11 | 25 |
| 2013 | 17 | 55 |
| 2014 | 25 | 57 |
| 2015 | 47 | 79 |
| 2016 | 37 | 71 |
| 2017 | 55 | 58 |
| 2018 | 35 | 45 |
| 2019 | 41 | 54 |
| 2020 | 42 | 56 |
| 2021 | 35 | 40 |
| 2022 | 18 | 34 |
| 2023 | 12 | 21 |
| 2024 | 7 | 17 |
| 2025 | 13 | 16 |
| 2026 | 12 | 11 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- D-amphetamine compounds, compositions, and processes for making and using the same15 Sep 2026US 12,735,388 B2Zevra Therapeutics, Inc.
- Stable compositions of functional ingredients and methods of making the same28 Jul 2026US 12,691,078 B2Nulixir Inc.
- Implantable devices for drug delivery with reduced burst release14 Jul 2026US 12,678,400 B2ReacX Pharmaceuticals, Inc.
- Implantable devices for drug delivery with reduced burst release14 Jul 2026US 12,678,401 B2ReacX Pharmaceuticals, Inc.
- Trimodal, precision-timed pulsatile release tablet16 Jun 2026US 12,653,791 B2Cingulate Therapeutics LLC
- Antiarrhythmic formulation27 Aug 2026US 2026/0248776 A1InCarda Therapeutics, Inc.
- Methadone Active Agents and Methods of Use Thereof6 Aug 2026US 2026/0226000 A1Ensysce Biosciences Inc.
- Injectable compositions of flecainide30 Jul 2026US 2026/0216160 A1Cipla Limited
- Liquid pharmaceutical composition containing flecainide and process for the preparation thereof23 Jul 2026US 2026/0207488 A1Colonis Pharma Ltd
- Anesthetic agent micro and nano particles, and methods of making and using the same21 May 2026US 2026/0137637 A1
Most cited
By later US patents
- Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine486US 10,299,720 B2The General Hospital Corporation · 2019
- Delivery of multiple doses of medications377US 5,837,284 A1998
- Methods and devices for providing prolonged drug therapy267US 6,919,373 B1Alza Corporation · 2005
- Methylphenidate modified release formulations210US 6,344,215 B12002
- Pharmaceutical formulation containing gelling agent198US 8,337,888 B2Purdue Pharma L. P. · 2012