Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine
AssigneeThe General Hospital Corporation
InventorsEmery N. Brown, Patrick L. Purdon
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AssigneeThe General Hospital Corporation
InventorsEmery N. Brown, Patrick L. Purdon
Estimating the term…
The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (MPH), amphetamine, modafinil, amantadine, caffeine, or analogs or derivatives thereof. In some embodiments, compositions comprising at least one or more anesthesia-reversing agents can be used to facilitate awakening from anesthesia without or decreasing occurrence of delirium, and can be used in methods to treat or prevent the symptoms associated with emergence delirium, as well as treat a subject oversedated with general an esthesia. The invention also relates to methods for administering these compositions comprising anesthesia-reversing agents to subjects and for use.
An electronic method for determining a state of consciousness from electroencephalogram (“EEG”) signals acquired from a subject experiencing an administration of at least one anesthetic agent or at least one drug to facilitate emergence from anesthesia, the electronic method comprising:
Dependencies are inferred from the claim text.