Implantable devices for drug delivery with reduced burst release
AssigneeReacX Pharmaceuticals, Inc.
InventorsRajesh A. Patel, Sunil Sreedharan, Sunil R. Bhonsle
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Abstract
The invention provides implantable drug delivery devices comprising a core comprising a polymer (or polymer blend) and one or more drugs or pharmaceutical substances, and an outer shell comprising a polymer (or polymer blend) and one or more porogen materials. The invention reduces burst release of drug. Pharmaceuticals such as triiodothyronine (T3) or ropinirole can be delivered by the devices.
Claims21
An implantable device for delivery of a pharmaceutical substance or drug, wherein the implantable device, after implantation, comprises:
- a core comprising:
- (i) a polymeric material consisting of poly(vinyl alcohol);
- and (ii) the pharmaceutical substance or drug;
- and
- a porous outer shell comprising poly(vinyl alcohol) and poly-L-lactic acid-co-glycolic acid, wherein the porous outer shell is free of the pharmaceutical substance or drug, the porous outer shell having a thickness of about 1 micrometer to about 5 micrometers,
- wherein the implantable device is rod-shaped and has a length of about 0.5 cm to 10 cm and a diameter of about 1 mm to about 8 mm, and wherein, after implantation into a patient, the drug diffuses through the porous outer shell.
An implantable device for delivery of a pharmaceutical substance or drug, wherein the implantable device, after implantation, comprises:
- a polymeric core consisting of poly(vinyl alcohol) and the pharmaceutical substance or drug;
- and
- a porous outer shell consisting of poly(vinyl alcohol) and poly-L-lactic acid-co-glycolic acid, wherein the porous outer shell is free of the pharmaceutical substance or drug, the porous outer shell having a thickness of about 1 micrometer to about 5 micrometers,
- wherein the implantable device is rod-shaped and has a length of about 0.5 cm to 10 cm in length, wherein the diameter of the implantable device is about 1 mm to about 7 mm, and wherein, after implantation into a patient, the drug diffuses through the porous outer shell.
Dependencies are inferred from the claim text.