C12N 15/1082
Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, hr-
Official title: {Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors}
C12N15/1082 (Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, hr-) appears on 357 US grants and 739 published applications in this corpus.
Search patents in C12N- Granted patents
- 357
- Published applications
- 739
- Assignees
- 341
- Inventors
- 1,438
- Latest grant
- 22 Sep 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1993 | 1 | 0 |
| 1994 | 1 | 0 |
| 1995 | 1 | 0 |
| 1996 | 2 | 0 |
| 1997 | 2 | 0 |
| 1998 | 3 | 0 |
| 1999 | 5 | 0 |
| 2000 | 2 | 0 |
| 2001 | 10 | 0 |
| 2002 | 11 | 20 |
| 2003 | 6 | 19 |
| 2004 | 3 | 15 |
| 2005 | 4 | 9 |
| 2006 | 5 | 18 |
| 2007 | 6 | 5 |
| 2008 | 5 | 6 |
| 2009 | 3 | 10 |
| 2010 | 5 | 10 |
| 2011 | 7 | 10 |
| 2012 | 4 | 18 |
| 2013 | 8 | 16 |
| 2014 | 24 | 41 |
| 2015 | 11 | 21 |
| 2016 | 10 | 31 |
| 2017 | 9 | 45 |
| 2018 | 10 | 40 |
| 2019 | 30 | 54 |
| 2020 | 30 | 56 |
| 2021 | 28 | 48 |
| 2022 | 24 | 36 |
| 2023 | 29 | 58 |
| 2024 | 26 | 62 |
| 2025 | 20 | 61 |
| 2026 | 12 | 30 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Integration of nucleic acid constructs into eukaryotic cells with a transposase from oryzias22 Sep 2026US 12,742,171 B2Dna Twopointo Inc.
- Compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy4 Aug 2026US 12,697,398 B2Yale University
- Method for screening target gene using CRISPRI system and uses thereof4 Aug 2026US 12,698,574 B2Chungang University Industry Academic Cooperation Foundation
- Method of enabling pooled-library based nucleic acid constructs screening2 Jun 2026US 12,644,117 B2Leadxpro AG
- Polypeptide linkers for use in engineered meganucleases2 Jun 2026US 12,644,135 B2Precision BioSciences, Inc.
- Contiguity Preserving Transposition8 Oct 2026US 2026/0308571 A1Illumina Cambridge Limited
- Method8 Oct 2026US 2026/0308574 A1Sania Tx Ltd
- Cas12 proteins and uses thereof8 Oct 2026US 2026/0308641 A1Reforgene Medicine
- Multiplex production and barcoding of genetically engineered cells24 Sep 2026US 2026/0286382 A1Brandeis University
- Methods for preparation and analysis of proximity-ligated nucleic acids from single cells17 Sep 2026US 2026/0275410 A1Arima Genomics, Inc.
Most cited
By later US patents
- CRISPR-Cas systems and methods for altering expression of gene products1,186US 8,697,359 B1Massachusetts Institute of Technology · 2014
- Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains568US 8,993,233 B2Massachusetts Institute of Technology · 2015
- CRISPR-Cas component systems, methods and compositions for sequence manipulation560US 8,795,965 B2Massachusetts Institute of Technology · 2014
- CRISPR-Cas component systems, methods and compositions for sequence manipulation529US 8,871,445 B2Massachusetts Institute of Technology · 2014
- Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation489US 8,865,406 B2Massachusetts Institute of Technology · 2014