C07K 1/1136
By reversible modification of the secondary, tertiary or quarternary structure
Official title: {by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents}
C07K1/1136 (By reversible modification of the secondary, tertiary or quarternary structure) appears on 177 US grants and 242 published applications in this corpus.
Search patents in C07K- Granted patents
- 177
- Published applications
- 242
- Assignees
- 167
- Inventors
- 505
- Latest grant
- 28 Oct 2025
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1983 | 1 | 0 |
| 1984 | 2 | 0 |
| 1985 | 0 | 0 |
| 1986 | 0 | 0 |
| 1987 | 5 | 0 |
| 1988 | 4 | 0 |
| 1989 | 3 | 0 |
| 1990 | 5 | 0 |
| 1991 | 3 | 0 |
| 1992 | 3 | 0 |
| 1993 | 1 | 0 |
| 1994 | 3 | 0 |
| 1995 | 0 | 0 |
| 1996 | 3 | 0 |
| 1997 | 4 | 0 |
| 1998 | 3 | 0 |
| 1999 | 3 | 0 |
| 2000 | 4 | 0 |
| 2001 | 2 | 1 |
| 2002 | 3 | 11 |
| 2003 | 7 | 9 |
| 2004 | 2 | 7 |
| 2005 | 4 | 12 |
| 2006 | 6 | 9 |
| 2007 | 5 | 10 |
| 2008 | 3 | 18 |
| 2009 | 4 | 11 |
| 2010 | 7 | 12 |
| 2011 | 7 | 10 |
| 2012 | 2 | 6 |
| 2013 | 5 | 9 |
| 2014 | 11 | 16 |
| 2015 | 8 | 15 |
| 2016 | 4 | 11 |
| 2017 | 8 | 11 |
| 2018 | 7 | 9 |
| 2019 | 10 | 14 |
| 2020 | 4 | 4 |
| 2021 | 8 | 9 |
| 2022 | 1 | 7 |
| 2023 | 3 | 4 |
| 2024 | 4 | 8 |
| 2025 | 5 | 6 |
| 2026 | 0 | 3 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Method for producing refolded protein by using flow microreactor, and protein refolding apparatus28 Oct 2025US 12,454,548 B2Ajinomoto Co., Inc.
- Sulfur (VI) fluoride compounds and methods for the preparation thereof19 Aug 2025US 12,390,424 B2The Scripps Research Institute
- Refolding proteins using a chemically controlled redox state8 Apr 2025US 12,269,843 B2Amgen Inc.
- Method for supporting thiol group-including compound4 Mar 2025US 12,240,919 B2Kaneka Corporation
- Method for treating a tissue defect with a collagen-containing membrane18 Feb 2025US 12,226,548 B2Orthocell Limited
- Protein folding agent, compound, protein folding method, pharmaceutical composition, and agent for suppressing cytotoxicity by transition metal3 Sep 2026US 2026/0258077 A1National University Corporation Tokyo University of Agriculture and Technology
- Enhancement and stabilisation of proteolytic activity of proteases6 Aug 2026US 2026/0226451 A1Phoenix Eagle Company Pty. Ltd.
- Substituted guanidino and amidino reagents and the use thereof for protein denaturation26 Feb 2026US 2026/0055135 A1Waters Technologies Corporation
- Method for constructing hotspot-derived peptide-nucleic acid hybrid molecules on basis of in vitro selection25 Sep 2025US 2025/0297036 A1
- Supramolecular Complex of a Biomolecule14 Aug 2025US 2025/0257111 A1
Most cited
By later US patents
- Multiwell droplet actuator, system and method132US 7,998,436 B2Advanced Liquid Logic, Inc. · 2011
- Protein crystallization screening and optimization droplet actuators, systems and methods124US 8,007,739 B2Advanced Liquid Logic, Inc. · 2011
- Stabilized alpha helical peptides and uses thereof119US 7,723,469 B2Dana-Farber Cancer Institute, Inc. · 2010
- Codon pair utilization80US 5,082,767 A1992
- Process for the recovery of human .beta.-interferon-like polypeptides78US 4,462,940 ACetus Corporation · 1984