C12Q 1/6862
Ligase chain reaction [lcr]
Official title: Ligase chain reaction [LCR]
C12Q1/6862 (Ligase chain reaction [lcr]) appears on 263 US grants and 239 published applications in this corpus.
Search patents in C12Q- Granted patents
- 263
- Published applications
- 239
- Assignees
- 146
- Inventors
- 417
- Latest grant
- 7 Jul 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1986 | 1 | 0 |
| 1987 | 0 | 0 |
| 1988 | 0 | 0 |
| 1989 | 1 | 0 |
| 1990 | 0 | 0 |
| 1991 | 0 | 0 |
| 1992 | 0 | 0 |
| 1993 | 1 | 0 |
| 1994 | 0 | 0 |
| 1995 | 6 | 0 |
| 1996 | 13 | 0 |
| 1997 | 18 | 0 |
| 1998 | 18 | 0 |
| 1999 | 19 | 0 |
| 2000 | 14 | 0 |
| 2001 | 22 | 0 |
| 2002 | 6 | 14 |
| 2003 | 12 | 14 |
| 2004 | 7 | 11 |
| 2005 | 3 | 7 |
| 2006 | 6 | 7 |
| 2007 | 6 | 12 |
| 2008 | 9 | 7 |
| 2009 | 3 | 11 |
| 2010 | 5 | 6 |
| 2011 | 1 | 8 |
| 2012 | 5 | 10 |
| 2013 | 3 | 10 |
| 2014 | 8 | 10 |
| 2015 | 2 | 6 |
| 2016 | 3 | 8 |
| 2017 | 7 | 6 |
| 2018 | 9 | 11 |
| 2019 | 6 | 23 |
| 2020 | 6 | 11 |
| 2021 | 11 | 6 |
| 2022 | 11 | 14 |
| 2023 | 4 | 10 |
| 2024 | 6 | 9 |
| 2025 | 7 | 7 |
| 2026 | 4 | 1 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Systems, compositions, and methods for target entity detection7 Jul 2026US 12,674,190 B2Mercy BioAnalytics, Inc.
- Method of ligation for the detection of abasic sites on a DNA target sequence7 Jul 2026US 12,674,191 B1
- Gene specific spatial rolling circle amplification and NGS sequencing30 Jun 2026US 12,668,838 B2Miltenyi Biotec GmbH
- Simplified polynucleotide sequence detection method10 Feb 2026US 12,545,951 B2Biofidelity Ltd
- Methods for non-invasive prenatal ploidy calling9 Dec 2025US 12,494,267 B2Natera, Inc.
- Recombinant ligases and uses thereof5 Mar 2026US 2026/0062742 A1Singular Genomics Systems, Inc.
- Composition for detecting cdna synthesis-based target gene using ligation method that does not use reverse transcription, and method for amplifying multiple ligation-assisted recombinase polymerase25 Dec 2025US 2025/0388960 A1Industrial Cooperation Foundation Jeonbuk National University
- Methods for amplifying polynucleotide sequences in situ13 Nov 2025US 2025/0346951 A1Singular Genomics Systems, Inc.
- Methods for non-invasive prenatal ploidy calling23 Oct 2025US 2025/0329411 A1Natera, Inc.
- Methods for non-invasive prenatal ploidy calling29 May 2025US 2025/0174301 A1Natera, Inc.
Most cited
By later US patents
- Rolling circle replication reporter systems1,228US 5,854,033 AYale University · 1998
- Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease941US 5,494,810 ACornell Research Foundation, Inc. · 1996
- Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions478US 6,027,889 ACornell Research Foundation, Inc. · 2000
- Detection of specific sequences in nucleic acids449US 4,883,750 AApplied Biosystems, LLC · 1989
- DNA sequencing by stepwise ligation and cleavage449US 5,599,675 ASpectragen, Inc. · 1997