C07D 475/08
With a nitrogen atom directly attached in position 2
Official title: with a nitrogen atom directly attached in position 2
C07D475/08 (With a nitrogen atom directly attached in position 2) appears on 166 US grants and 143 published applications in this corpus.
Search patents in C07D- Granted patents
- 166
- Published applications
- 143
- Assignees
- 99
- Inventors
- 367
- Latest grant
- 19 May 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1976 | 1 | 0 |
| 1977 | 1 | 0 |
| 1978 | 5 | 0 |
| 1979 | 1 | 0 |
| 1980 | 1 | 0 |
| 1981 | 2 | 0 |
| 1982 | 1 | 0 |
| 1983 | 4 | 0 |
| 1984 | 3 | 0 |
| 1985 | 2 | 0 |
| 1986 | 3 | 0 |
| 1987 | 2 | 0 |
| 1988 | 5 | 0 |
| 1989 | 3 | 0 |
| 1990 | 2 | 0 |
| 1991 | 4 | 0 |
| 1992 | 1 | 0 |
| 1993 | 1 | 0 |
| 1994 | 5 | 0 |
| 1995 | 1 | 0 |
| 1996 | 5 | 0 |
| 1997 | 1 | 0 |
| 1998 | 2 | 0 |
| 1999 | 5 | 0 |
| 2000 | 2 | 0 |
| 2001 | 4 | 0 |
| 2002 | 2 | 3 |
| 2003 | 4 | 13 |
| 2004 | 5 | 8 |
| 2005 | 3 | 2 |
| 2006 | 5 | 9 |
| 2007 | 7 | 10 |
| 2008 | 2 | 8 |
| 2009 | 3 | 2 |
| 2010 | 7 | 9 |
| 2011 | 3 | 2 |
| 2012 | 4 | 2 |
| 2013 | 3 | 8 |
| 2014 | 6 | 9 |
| 2015 | 6 | 4 |
| 2016 | 7 | 7 |
| 2017 | 6 | 5 |
| 2018 | 4 | 3 |
| 2019 | 3 | 4 |
| 2020 | 2 | 5 |
| 2021 | 2 | 11 |
| 2022 | 1 | 3 |
| 2023 | 4 | 2 |
| 2024 | 3 | 2 |
| 2025 | 6 | 7 |
| 2026 | 1 | 5 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Recent patents
- Compound used as RET kinase inhibitor and application thereof19 May 2026US 12,629,358 B2Tyk Medicines, Inc.
- Gamma polyglutamated aminopterin and uses thereof8 Jul 2025US 12,350,271 B2L.E.A.F. Holdings Group LLC
- Alpha polyglutamated tetrahydrofolates and uses thereof24 Jun 2025US 12,336,994 B2L.E.A.F. Holdings Group LLC
- Alpha polyglutamated aminopterin and uses thereof27 May 2025US 12,310,966 B2L.E.A.F. Holdings Group LLC
- Gamma polyglutamated methotrexate and uses thereof6 May 2025US 12,290,518 B2L.E.A.F. Holdings Group LLC
- Gamma polyglutamated aminopterin and uses thereof23 Jul 2026US 2026/0207609 A1L.E.A.F. Holdings Group LLC
- Pralatrexate and cop combination for the treatment of patients with peripheral t cell lymphoma14 May 2026US 2026/0130919 A1Acrotech Biopharma Inc.
- Gamma polyglutamated methotrexate and uses thereof26 Feb 2026US 2026/0053806 A1L.E.A.F. Holdings Group LLC
- Alpha polyglutamated aminopterin and uses thereof26 Feb 2026US 2026/0053807 A1L.E.A.F. Holdings Group LLC
- Alpha polyglutamated tetrahydrofolates and uses thereof19 Feb 2026US 2026/0048054 A1L.E.A.F. Holdings Group LLC
Most cited
By later US patents
- Certain alkylene diamine-substituted heterocycles126US 6,506,762 B1Neurogen Corporation · 2003
- Pharmaceutical compositions84US 4,425,346 ASmith and Nephew Associated Companies Limited · 1984
- Multibinding inhibitors of microsomal triglyceride transferase protein58US 6,288,234 B1Advanced Medicine, Inc. · 2001
- Aminomethyl derivatives of biologically active substances, and enhanced delivery thereof across topical membranes46US 4,845,081 AUniversity of Florida · 1989
- Folic acid derivatives43US 6,291,673 B1Purdue Research Foundation · 2001