Gamma polyglutamated aminopterin and uses thereof
AssigneeL.E.A.F. Holdings Group LLC
InventorsClet NIYIKIZA, Victor Mandla MOYO
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Abstract
The disclosure relates generally to gamma polyglutamated aminopterin compositions, including delivery vehicles such as liposomes containing the gamma polyglutamated aminopterin, and methods of making and using the gamma polyglutamated aminopterin compositions to treat hyperproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., inflammation and autoimmune diseases such as rheumatoid arthritis).
Claims21
-94. (canceled)
A liposomal composition comprising a liposome encapsulating a gamma polyglutamated aminopterin comprising 3-10 glutamyl groups containing gamma carboxyl group linkages, wherein at least one of the glutamyl groups of the gamma polyglutamated aminopterin is in the D-form, and wherein the liposome has a diameter in the range of 20 nm to 200 nm, is pegylated and does not contain a targeting moiety having specific affinity for a surface antigen on a target cell.
A method of killing a hyperproliferative cell comprising contacting a hyperproliferative cell with the liposomal composition of claim 1.
Dependencies are inferred from the claim text.