C40B 50/00
Methods of creating libraries
Official title: Methods of creating libraries, e.g. combinatorial synthesis
C40B50/00 (Methods of creating libraries) appears on 1,422 US grants and 2,199 published applications in this corpus.
Search patents in C40B- Granted patents
- 1,422
- Published applications
- 2,199
- Assignees
- 836
- Inventors
- 3,799
- Latest grant
- 6 Oct 2026
Filings by year
| Year | Granted patents | Published applications |
|---|---|---|
| 1977 | 1 | 0 |
| 1978 | 0 | 0 |
| 1979 | 0 | 0 |
| 1980 | 0 | 0 |
| 1981 | 0 | 0 |
| 1982 | 0 | 0 |
| 1983 | 0 | 0 |
| 1984 | 0 | 0 |
| 1985 | 0 | 0 |
| 1986 | 1 | 0 |
| 1987 | 0 | 0 |
| 1988 | 0 | 0 |
| 1989 | 2 | 0 |
| 1990 | 0 | 0 |
| 1991 | 2 | 0 |
| 1992 | 1 | 0 |
| 1993 | 2 | 0 |
| 1994 | 4 | 0 |
| 1995 | 8 | 0 |
| 1996 | 10 | 0 |
| 1997 | 19 | 0 |
| 1998 | 26 | 0 |
| 1999 | 29 | 0 |
| 2000 | 31 | 0 |
| 2001 | 46 | 11 |
| 2002 | 41 | 83 |
| 2003 | 59 | 135 |
| 2004 | 42 | 111 |
| 2005 | 28 | 68 |
| 2006 | 34 | 84 |
| 2007 | 24 | 52 |
| 2008 | 27 | 79 |
| 2009 | 27 | 60 |
| 2010 | 33 | 78 |
| 2011 | 39 | 77 |
| 2012 | 31 | 71 |
| 2013 | 29 | 57 |
| 2014 | 44 | 67 |
| 2015 | 40 | 58 |
| 2016 | 51 | 76 |
| 2017 | 46 | 78 |
| 2018 | 64 | 111 |
| 2019 | 77 | 137 |
| 2020 | 88 | 142 |
| 2021 | 94 | 129 |
| 2022 | 66 | 98 |
| 2023 | 70 | 97 |
| 2024 | 75 | 106 |
| 2025 | 72 | 76 |
| 2026 | 39 | 58 |
By publication year. Applications have been published since 2001. 2026 runs to 8 Oct.
Subgroups
Granted patents
- C40B 50/14Solid phase synthesis, i.e. wherein one or more library building blocks are644
- C40B 50/06Biochemical methods551
- C40B 50/08Liquid phase synthesis, i.e. wherein all library building blocks are in liquid232
- C40B 50/04Methods of creating libraries: using dynamic combinatorial chemistry techniques46
Recent patents
- Detection and prediction of infectious disease6 Oct 2026US 12,753,448 B2Karius, Inc.
- Compositions and methods for accurately identifying mutations29 Sep 2026US 12,747,473 B2Fred Hutchinson Cancer Center
- Peptide library production method15 Sep 2026US 12,735,809 B2The University of Tokyo
- Systems and methods for transfer of reagents between droplets15 Sep 2026US 12,735,810 B210x Genomics, Inc.
- Method for detecting the mutation and methylation of tumor-specific genes in ctDNA11 Aug 2026US 12,703,884 B2Cancer Hospital, Chinese Academy of Medical Sciences
- Methods for identifying cross-contamination among sequential nucleic acid amplification reactions24 Sep 2026US 2026/0286436 A1Wisconsin Alumni Research Foundation
- Methods and compositions for amplification and sequencing of genome and epigenome17 Sep 2026US 2026/0275408 A1Board of Regents, The University of Texas System
- Methods for preparation and analysis of proximity-ligated nucleic acids from single cells17 Sep 2026US 2026/0275410 A1Arima Genomics, Inc.
- Methods, compositions, and kits for inhibiting formation of adapter dimers17 Sep 2026US 2026/0275575 A1Revvity Health Sciences, Inc.
- Systems and methods for transfer of reagents between droplets10 Sep 2026US 2026/0265956 A110x Genomics, Inc.
Most cited
By later US patents
- Method and apparatus for conducting an array of chemical reactions on a support surface1,036US 5,474,796 AProtogene Laboratories, Inc. · 1995
- Methods for in vitro recombination882US 5,605,793 AAffymax Technologies N.V. · 1997
- Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support822US 5,288,514 AThe Regents of the University of California · 1994
- DNA mutagenesis by random fragmentation and reassembly791US 5,830,721 AAffymax Technologies N.V. · 1998
- Methods for generating polynucleotides having desired characteristics by iterative selection and recombination707US 5,811,238 AAffymax Technologies N.V. · 1998