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US RE45,020 E1Granted
Ribonucleotide reductase inhibitors and methods of use
AssigneeCity of Hope
InventorsDavid Horne, Christopher Lincoln
Life of this patent
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Abstract
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
Claims2
A method of synthesizing a compound having the structure:
- comprising the steps:
- (a) converting veratrole to 1-(3,4-dimethoxyphenyl)-2-phenylethanone;
- (b) converting 1-(3,4-dimethoxyphenyl)-2-phenylethanone to 4-(3,4-dimethoxyphenyl)-5-phenylthiazol-2-amine;
- (c) converting 4-(3,4-dimethoxyphenyl)-5-phenylthiazol-2-amine to N-(4-(3,4-dimethoxyphenyl)-5-phenylthiazol-2-yl)-3,4-dimethoxybenzamide;
- and
- (d) converting N-(4-(3,4-dimethoxyphenyl)-5-phenylthiazol-2-yl)-3,4-dimethoxybenzamide to
3 more elements
Dependencies are inferred from the claim text.