Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells
AssigneeCornerstone Pharmaceuticals, Inc.
InventorsRobert G. L. Shorr, Robert J. Rodriguez
Life of this patent
Estimating the term…
Abstract
Nanoparticles made from a select group of lipids and optionally containing a therapeutically active agent are employed in pharmaceutical compositions for delivery to targeted tissues and/or cells for the treatment or diagnosis of such diseases as cancer.
Claims23
A method of treating a targeted tissue or cell comprising administering to said targeted tissue or cell an effective amount of a pharmaceutical composition comprising non-gas containing nanoparticles capable of being internalized within a target tissue or cell sufficient to achieve a desired effect comprising, said non-gas containing nanoparticles comprising:
- a mixture of select lipids comprising:
- a) at least one first member selected from the group consisting of glycerol monoesters of saturated carboxylic acids containing from about 10 to 18 carbon atoms and aliphatic alcohols containing from about 10 to 18 carbon atoms;
- b) at least one second member selected from the group consisting of sterol aromatic acid esters;
- c) at least one third member selected from the group consisting of sterols and sterol esters of aliphatic carboxylic acids containing from about 1 to 18 carbon atoms;
- d) at least one fourth member selected from the group consisting of glycerol and glycerol di- and tri-esters of aliphatic carboxylic acids containing from about 10 to 18 carbon atoms and aliphatic alcohols containing from about 10 to 18 carbon atoms;
- and
- e) at least one therapeutically active agent, wherein said pharmaceutical composition is produced by processing through a microfluidizer.
Dependencies are inferred from the claim text.