Eye device
AssigneeEyed Pharma
InventorsJean-Marie Rakic, Jean-Michel Foidart
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Abstract
The invention provides a sustained release intraocular drug delivery device comprising: (a) a polymeric matrix core into which at least one therapeutic agent is mixed, and; (b) a polymeric coating completely surrounding said polymeric matrix material; wherein said polymeric matrix core and polymeric coating are insoluble and inert in ocular fluids, and wherein said sustained release intraocular drug delivery device has a compliant annular segment shape and is to be inserted into the sulcus of the intact and/or pseudophakic eye.
Claims30
A sustained release intraocular drug delivery device having the shape of a compliant annular segment configured for a sulcus of a human eye, comprising:
- (a) an annular rod shaped solid polymeric matrix core into which at least one therapeutic agent is mixed, and;
- (b) a solid polymeric coating completely surrounding said polymeric matrix material;
- wherein said polymeric matrix core and polymeric coating are insoluble and inert in ocular fluids, and wherein said sustained release intraocular drug delivery device has a cross sectional diameter ranging from 0.10 to 0.80 mm,
- wherein the annular segment ranges from 90 to 360 degrees of the ring;
- and
- wherein the polymeric coating regulates the release of the therapeutic agent contained in the polymeric matrix material.
A process for preparing a sustained release intraocular drug delivery device, comprising:
- mixing the at least one therapeutic agent with an insoluble and inert polymer;
- molding and/or extruding said mixture to form a solid polymeric matrix core;
- and,
- providing the resulting polymeric matrix core with a polymeric coating, wherein the polymeric coating is a solid and completely surrounding said polymeric matrix material;
- wherein said polymeric matrix core and polymeric coating are insoluble and inert in ocular fluids, and
- wherein said sustained release intraocular drug delivery device forms a compliant annular segment having a cross sectional diameter ranging from 0.10 to 0.80 mm and length sufficient to extend along 90 to 360 degrees of the sulcus of the human eye.
Dependencies are inferred from the claim text.