Anti-thrombogenic grafts
AssigneeYale University
InventorsSashka Dimitrievska, Laura Niklason
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Abstract
The present invention provides anti-thrombogenic compositions, including anti-thrombogenic vascular grafts. In certain embodiments, the compositions comprise decellularized tissue coated with an anti-thrombogenic coating. The present invention also provides methods of preparing anti-thrombogenic compositions and methods of treatment comprising implanting the anti-thrombogenic compositions into a subject in need thereof.
Claims7
A composition comprising a substrate having at least one surface coated with an anti-thrombogenic coating, wherein the anti-thrombogenic coating comprises a first layer comprising a hydrogel and a second layer comprising an anti-coagulant, wherein the first layer contacts the substrate, and wherein the substrate is decellularized tissue.
Dependencies are inferred from the claim text.