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US 9,969,985 B2Granted
Modified human rotaviruses and uses therefor
AssigneeMurdoch Childrens Research Institute
InventorsCarl Kirkwood, Ruth Frances Bishop, Graeme Laurence Barnes
Life of this patent
Estimating the term…
Abstract
The present disclosure relates generally to the field of viral vaccines. Particularly, the present disclosure provides a modified Vero-adapted human rotavirus strain and a culturing method to produce high titer virus, a rotavirus vaccine, vaccination protocols and diagnostic and prognostic assays.
Claims4
An isolated Vero-adapted rotavirus RV3 strain comprising at least one of a NSP2 nucleotide sequence comprising SEQ ID NO:
- 33, a NSP4 nucleotide sequence comprising SEQ ID NO:
- 37, a NSP5/6 nucleotide sequence comprising SEQ ID NO:
- 29, a VP1 nucleotide sequence comprising SEQ ID NO:
- 49, a VP3 nucleotide sequence comprising SEQ ID NO:
- 57, a VP4 nucleotide sequence comprising SEQ ID NO:
- 61, a NSP4 amino acid sequence comprising SEQ ID NO:
- 38, a NSP5 amino acid sequence comprising SEQ ID NO:
- 30, a VP1 amino acid sequence comprising SEQ ID NO:
- 50, a VP3 amino acid sequence comprising SEQ ID NO:
- 58, or a VP4 amino acid sequence comprising SEQ ID NO:
- 62.
8 more elements
Dependencies are inferred from the claim text.