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US 9,944,019 B2Granted
Tip-loaded microneedle arrays for transdermal insertion
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon University
InventorsLouis D. Falo, Jr., Geza Erdos, O. Burak Ozdoganlar
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Abstract
A method of forming a microneedle array can include forming a microneedle array that has one or more bioactive component. The microneedle array can include a base portion and plurality of microneedles extending from the base portion, and the one or more bioactive components are present in a higher concentration in the plurality of microneedles than in the base portion.
Claims14
A dissolvable microneedle array for transdermal insertion into a patient comprising:
- one or more bioactive components;
- a base portion;
- and
- a plurality of microneedles extending from the base portion, the plurality of microneedles comprising a top half and a bottom half
- wherein the one or more bioactive components are concentrated in the top half of the microneedles,
- wherein the base portion and the plurality of microneedles comprise a plurality of layers of dissoluble biocompatible material,
- wherein the dissoluble biocompatible material define a shape of the plurality of microneedles, the one or more bioactive components are contained in the plurality of layers, and at least some of the plurality of layers that contain the one or more bioactive components are spatially separated from others of the plurality of layers that contain the one or more bioactive components.
4 more elements
Dependencies are inferred from the claim text.