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US 9,931,419 B2Granted
Methods and compositions for liposomal formulation of antigens and uses thereof
AssigneesMolecular Express, Inc., The Regents of the University of California
InventorsGary Fujii, Francis C. Szoka, Jr., Douglas S. Watson
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Abstract
The present invention relates to liposomal vaccine compositions, methods for the manufacture thereof, and methods for the use thereof to stimulate an immune response in an animal. These compositions comprise dimyristoylphosphatidylcholine (“DMPC”); either dimyristoylphosphatidylglycerol (“DMPG”) or dimyristoyltrimethylammonium propane (“DMTAP”) or both DMPC and DMTAP; and at least one sterol derivative providing a covalent anchor for one or more immunogenic polypeptide(s) or carbohydrate(s).
Claims21
A composition comprising:
- a) an aqueous vehicle;
- and
- b) liposomes comprising
- (i) dimyristoylphosphatidylcholine (“DMPC”),
- (ii) one or more lipids selected from the group consisting of dimyristoylphosphatidylglycerol (“DMPG”), and dimyristoyltrimethylammonium propane (“DMTAP”), and
- (iii) at least one sterol derivative,
- at relative percentages of 50%-98% (i):1%-25% (ii):1%-25% (iii);
- and
- wherein said sterol derivative comprises a reactive group selected from the group consisting of imidoesters, N-hydroxysuccinimidyl (“NHS”) esters, maleimides, alkyl halides, aryl halides, α-haloacyls, pyridyl disulfides, carbodiimides, glyoxals, amines, hydrazides, and arylazides.
6 more elements
Dependencies are inferred from the claim text.