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US 9,920,122 B2Granted
Compositions and methods to enhance the immune system
AssigneeStichting Sanquin Bloedvoorziening
InventorTimo Kars van den Berg
Life of this patent
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Abstract
The invention relates to the field of molecular medicine. In particular, it relates to compositions and methods to enhance the clearance of aberrant cells, e.g. cancer cells or virus-infected cells, by the host's immune system. Provided is a composition comprising (i) a therapeutic compound that can trigger a host's immune effector cells against an aberrant cell, such as a therapeutic antibody, and (ii) at least one agent capable of reducing or preventing inhibitory signal transduction initiated via SIRPalpha.
Claims17
A composition comprising
- (i) a therapeutic compound that can trigger a host's immune effector cells against a cancer cell, wherein said therapeutic compound is a therapeutic antibody comprising a human or non-human primate IgG Fc portion, wherein the therapeutic antibody induces antibody-dependent cellular cytotoxicity (ADCC), and
- (ii) at least one agent capable of reducing or preventing inhibitory signal transduction initiated via SIRPα, wherein said agent is an anti-SIRPα antibody or a Fab fragment, a F(ab′)2 fragment or a scFv fragment thereof.
A composition comprising
- (i) a therapeutic antibody selected from the group consisting of rituximab, trastuzumab, alemtuzumab, bevacizumab, cetuximab, and panitumumab, and
- (ii) at least one agent capable of reducing or preventing inhibitory signal transduction initiated via SIRPα, wherein said agent is an anti-SIRPα antibody or a Fab fragment, a F(ab′)2 fragment or a scFv fragment thereof.
Dependencies are inferred from the claim text.