Portable devices for detection of antibodies against therapeutic drugs
AssigneeConquerAb Inc.
InventorMaria D. F. S. Barbosa
Life of this patent
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Abstract
Portable devices for anti-drug antibodies (ADAs) testing are provided. These devices can be used in various applications, including but not restricted to the following: uniform testing of patients for ADAs; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; scientific guidance for discovering therapeutic drugs; therapeutic drug development; postmarketing surveillance of therapeutic drugs.
Claims19
A portable device comprising:
- a sample-receiving port adjacent to a sample-collecting pad;
- a conjugate pad comprising labeled antibodies capable of binding to a constant region of an anti-drug antibody;
- and
- a membrane comprising a capture agent comprising a chimeric protein comprising a therapeutic drug and a constant region of a different antibody;
- wherein the therapeutic drug is a variable region of a therapeutic antibody that is capable of binding to anti-drug antibodies that are specific to the therapeutic drug;
- wherein the constant region is from a different species than the species producing the anti-drug antibodies to be detected;
- wherein a sample contacted with the sample-collecting pad would laterally flow through the conjugate pad and subsequently to the membrane;
- and
- wherein the anti-drug antibodies are human anti-drug antibodies.
A portable device for testing human anti-drug antibodies in tissues and body fluids, comprising:
- a sample-receiving port adjacent to a sample-collecting pad;
- a conjugate pad comprising labeled entities capable of binding to a constant region of a human anti-drug antibody;
- and
- a membrane comprising a capture agent comprising a chimeric protein comprising a therapeutic drug and a constant region of an antibody;
- wherein the therapeutic drug is capable of binding to human anti-drug antibodies that are specific to the therapeutic drug;
- wherein the constant region is from a different species than the species producing the anti-drug antibody to be detected;
- and
- wherein a sample contacted with the sample-collecting pad would laterally flow through the conjugate pad and subsequently to the membrane.
Dependencies are inferred from the claim text.