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US 9,897,605 B2Granted
Porcine torque teno virus vaccines and diagnosis
AssigneeVirginia Tech Intellectual Properties, Inc.
InventorsXiang-Jin Meng, Yaowei Huang
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AssigneeVirginia Tech Intellectual Properties, Inc.
InventorsXiang-Jin Meng, Yaowei Huang
Estimating the term…
The present invention provides four purified preparation containing a polynucleic acid molecule encoding porcine Torque teno virus (PTTV) genotypes or subtypes PTTV1a-VA, PTTV1b-VA, PTTV2b-VA, and PTTV2c-VA. The present invention also provides infectious DNA clones, biologically functional plasmid or viral vector containing the infectious nucleic acid genome molecule of the same. The present invention further provides live, attenuated, vector-expressed and purified recombinant capsid subunit or killed viral vaccines for protection against PTTV infection. The present invention additionally provides subunit vaccines comprising PTTV specific gene products, especially ORF1 capsid gene product for protection against PTTV infection. Further, the present invention provides methods for diagnosing PTTV infection via polymerase chain reaction (PCR) using specific primer for PTTV1, PTTV2, and individual PTTV1 genotypes. Finally, the present invention provides methods for diagnosing PTTV infection via immunological methods, e.g., enzyme-linked immunoabsorbent assay (ELISA) and Western blot using PTTV specific antigens for detecting serum PTTV specific antibodies.
A vaccine comprising at least one adjuvant in an immunologically effective amount and a Porcine Torque Teno Virus open reading frame 1 (ORF1) protein according to SEQ ID NO:
A vaccine for protecting against a Porcine Torque Teno Virus (PTTV) infection, wherein the vaccine comprises at least one adjuvant and a recombinant protein comprising amino acids 310 to 625 of SEQ ID NO:
An immunogenic composition comprising at least one adjuvant and a recombinant subunit capsid protein or immunogenic fragment thereof expressed from a bacterial or baculovirus expression system wherein the capsid protein or immunogenic fragment thereof comprises a Porcine Torque Teno Virus polypeptide represented by amino acids 363 to 375 of SEQ ID NO:
A plasmid or baculovirus vector encoding a recombinant capsid protein or immunogenic fragment thereof wherein the recombinant capsid protein or immunogenic fragment comprises a Porcine Torque Teno Virus polypeptide represented by amino acids 363 to 375 of SEQ ID NO:
Dependencies are inferred from the claim text.