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US 9,890,141 B2Granted
Crystalline pharmaceutical and methods of preparation and use thereof
AssigneeSarcode Bioscience Inc.
InventorJohn Burnier
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Abstract
Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention.
Claims4
A composition comprising an isolated compound of Formula I:
- wherein said compound is synthesized according to a method comprising the steps:
- performing hydrolysis of Formula AA with a base:
- wherein R is a carbon containing moiety;
- and
- isolating the compound of Formula I,
- wherein the hydrolysis is performed in a solution comprising acetone, the composition is essentially free of a chemical catalyst, and the compound of Formula I is isolated by way of recrystallization from a solution comprising acetone.
3 more elements
Dependencies are inferred from the claim text.