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US 9,873,152 B2Granted
Nanoporous gold nanoparticles as high-payload molecular cargos, photothermal/photodynamic therapeutic agents, and ultrahigh surface-to-volume plasmonic sensors
AssigneeUniversity of Houston System
InventorWei-Chuan Shih
Life of this patent
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Abstract
A nanoporous gold disk (NPGD) as a novel surface-enhanced Raman spectroscopy (SERS) substrate. NPGD has SERS enhancement factor similar to that of gold nanoshells, but allows, for example, at least three times more benzenethiol molecules to be attached to its surface due to large surface-to-volume ratio. The high capacity enables the rapid detection of attomole-level benzenethiol molecules with relatively high detector temperatures. Additionally, a fabrication process to make NPGD with controlled size and highly reproducible SERS activities.
Claims13
A nanoporous gold structure comprising:
- a plurality of nanoporous gold discs, each nanoporous gold disc comprising:
- a substrate layer;
- an adhesion layer disposed in association with the substrate layer;
- and
- a porous gold layer disposed in association with the adhesion layer, wherein the porous gold layer comprises a nanoporous 3-dimensional network of pores extending throughout the porous gold layer's entire volume and is adapted for adsorbing and releasing molecules into and from the pores thereof, wherein the pores in the porous gold layer have a width ranging from about 5 nanometers to about 20 nanometers, and wherein the nanoporous gold structure has a red-shifted plasmon resonance peak of at least 650 nm.
2 more elements
A nanoporous gold structure comprising:
- a plurality of nanoporous gold discs, each nanoporous gold disc comprising:
- a substrate layer;
- and
- a porous gold layer disposed in association with the substrate layer, wherein the porous gold layer comprises a nanoporous 3-dimensional network of pores extending throughout the porous gold layer's entire volume and is adapted for adsorbing and releasing molecules into and from the pores thereof, wherein the pores in the porous gold layer have a width ranging from about 5 nanometers to about 20 nanometers, and wherein the nanoporous gold structure has a red-shifted plasmon resonance peak of at least 650 nm.
1 more element
Dependencies are inferred from the claim text.