Method system and device for assessing insulin sensitivity
AssigneeRoche Diabetes Care, Inc.
InventorsOfer Yodfat, Gali Shapira, Iddo Gescheit
Life of this patent
Estimating the term…
Abstract
A method and a system for determining insulin sensitivity (IS) is described. In one aspect the method and the system can be implemented by receiving a first parameter corresponding to an insulin dose in a subcutaneous tissue; applying a first kinetic model to obtain a plasma insulin concentration based on the first parameter; receiving a second parameter corresponding to a plasma glucose concentration; determining the insulin sensitivity (IS) based on the plasma insulin concentration and the second parameter.
Claims15
A method for determining an insulin dose to be administered by an insulin delivery device based on a determined insulin sensitivity (IS), comprising:
- receiving, via a subcutaneous glucose sensing apparatus, a first parameter corresponding to a first insulin dose value administered by an insulin dispensing apparatus in a subcutaneous tissue of a patient;
- applying a first kinetic model to obtain a plasma insulin concentration based on the first parameter;
- sensing a glucose concentration value, via the glucose sensing apparatus, via a cannula that is penetrating and residing in skin of the patient, residing in the subcutaneous tissue;
- receiving a second parameter corresponding to the glucose concentration value from the glucose sensing apparatus;
- determining the insulin sensitivity (IS) based on the plasma insulin concentration and the second parameter;
- determining a second insulin dose value based on the determined insulin sensitivity to be administered by the insulin dispensing apparatus;
- reevaluating the insulin sensitivity (IS) after a predetermined period of time since a last food bolus via an insulin sensitivity assessment feature;
- and
- delivering an insulin bolus via the cannula coupled to the insulin dispensing apparatus.
A method for determining an insulin dose to be administered by an insulin delivery device based on a determined insulin sensitivity (IS), comprising:
- receiving, via an insulin delivery device which comprises a housing containing therein a glucose sensing apparatus and an insulin dispensing apparatus, and having a cannula extending from the housing, a first parameter corresponding to a first insulin dose value administered by the insulin dispensing apparatus in a subcutaneous tissue of a patient;
- applying a first kinetic model to obtain a plasma insulin concentration based on the first parameter;
- sensing a glucose concentration value, via the glucose sensing apparatus, via the cannula that is penetrating and residing in skin of the patient, residing in the subcutaneous tissue;
- receiving a second parameter corresponding to the glucose concentration value from the glucose sensing apparatus;
- determining the insulin sensitivity (IS) based on the plasma insulin concentration and the second parameter;
- determining a second insulin dose value based on the determined insulin sensitivity to be administered by the insulin dispensing apparatus;
- and
- delivering the second insulin bolus value via the cannula.
Dependencies are inferred from the claim text.