Methods, compositions and techniques for polydimethylsiloxane surface modifications
AssigneeOrthobond, Inc.
InventorsRandy Clevenger, Se-Ho Kim, Jordan Katz, Carlos Caicedo-Carvajal
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Abstract
Disclosed are novel compositions and methods for making a polymer substrate and a ligand that includes a proximal portion with a photoactive compound bound to the polymer substrate, a terminal portion with an anti-infective/anti-microbial compound, and a reactive portion attaching the proximal portion and the terminal portion.
Claims68
A composition comprising a polymer substrate, wherein the polymer substrate comprises a polysiloxane material, and a ligand covalently bonded to the polymer substrate, the ligand comprising
- (i) a proximal portion based on a photoactive compound, the proximal portion covalently bonded to the polymer substrate,
- (ii) a terminal portion comprising a covalently bonded anti-microbial compound, and
- (iii) a reactive portion covalently attaching the proximal portion and the terminal portion.
A method of covalently bonding a ligand to a surface of a polymer substrate, the ligand comprising
- (i) a proximal portion based on a photoactive compound, the proximal portion covalently bonded to the polymer substrate,
- (ii) a terminal portion comprising a covalently bonded anti-microbial compound, and
- (iii) a reactive portion covalently attaching the proximal portion and the terminal portion;
- the method comprising:
- applying a composition to a surface of the polymer substrate, the composition comprising a linker attached to a reactive portion;
- applying photocatalytic ultraviolet light to the surface to attach the linker to the polymer substrate;
- and
- attaching a terminal portion comprising an anti-microbial compound to the reactive portion using atom transfer radical polymerization to render the surface antimicrobial.
Dependencies are inferred from the claim text.