Hydroxyl-polymer-drug-protein conjugates

A polymeric scaffold useful to conjugate with a protein based recognition-molecule (PBRM), the scaffold comprising a linear, branched or cyclic polymer having one or more —OH groups connected to the polymer, one or more

• connected to the polymer, and one or more
• connected to the polymer, wherein:
• the polymer is a hydroxyl polymer having a molecular weight ranging from 2 kDa to 300 kDa and the polymer is not a polyacetal or a polyketal,
• each occurrence of D is independently a therapeutic agent having a molecular weight ≦5 kDa;
• LD1 is a carbonyl-containing moiety;
• each occurrence of
• independently is a first linker that contains a biodegradable bond so that when the bond is broken, D is released in an active form for its intended therapeutic effect;
• in which each u is 1, and the
• between LD1 and D denotes direct or indirect attachment of D to LD1;
• and
• each occurrence of
• independently is a second linker not yet connected to PBRM, in which LP2 is a moiety containing a functional group that is capable of forming a covalent bond with a functional group of a PBRM, each u is 1, and the
• between LD1 and LP2 denotes direct or indirect attachment of LP2 to LD1, and each occurrence of the second linker is distinct from each occurrence of the first linker.