Facile method for making non-toxic biomedical compositions comprising hybrid metal-polymer microparticles

A method of making a plasmonic hybrid metal-polymer microparticle complex comprising the steps of:

• forming a hybrid metal-polymer microparticle with a tunable near-infrared (NIR) plasmon absorption in an aqueous, biocompatible solution by
• providing an aqueous biocompatible solution;
• combining a metal (I) composition wherein the metal (I) is silver and one or more polymeric materials in the aqueous biocompatible solution wherein one or more polymeric materials comprise Nylon, polyurethane, or polyacrylonitrile;
• applying an electromagnetic radiation for 30-40 minutes to the metal (I) composition to convert the metal (I) composition to a metal (0) composition;
• forming one or more hybrid metal-polymer microparticles from the metal (0);
• capping the one or more hybrid metal-polymer microparticles;
• and
• stabilizing the one or more hybrid metal-polymer microparticles with the one or more polymeric materials to prevent agglomeration and to provide the NIR plasmon absorption of the one or more hybrid metal-polymer microparticles between 700 nm-1200 nm;
• and
• forming one or more stabilized hybrid metal-polymer microparticles.

A hybrid metal-polymer microparticle composite made by:

• providing an aqueous biocompatible solution;
• combining a metal (I) composition and one or more polymeric materials and one or more nanofibers;
• applying an electromagnetic radiation for 30-40 minutes to the metal (I) composition;
• converting the metal (I) composition to a metal (0) composition;
• forming one or more hybrid metal-polymer microparticles from the metal (0);
• capping the one or more hybrid metal-polymer microparticles;
• stabilizing the one or more hybrid metal-polymer microparticles with the one or more polymeric materials to prevent agglomeration;
• forming a hybrid metal-polymer microparticle composite;
• and
• tuning of a near-infrared (NIR) plasmon absorption of the one or more hybrid metal-polymer microparticles between 700 nm-1200 nm by varying time of exposure, concentrations of the one or more polymeric materials, concentrations of the metal (I) composition or a combination thereof.