Photoimmunoconjugates for use in photodynamic therapy
AssigneesFraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V., Rheinisch-Westfaelische Technische Hochschule Aachen
InventorsStefan Barth, Mehmet K. Tur, Ahmad Hussain
Life of this patent
Estimating the term…
Abstract
A compound comprising a photosensitizer covalently coupled to a protein selected from the group consisting of antibodies or their derivatives or fragments thereof, synthetic peptides such as scFv, mimotopes which bind CD antigens, cytokine receptors, interleukin receptors, hormone receptors, growth factor receptors, more particularly tyrosine kinase growth factor receptor of the ErbB family, wherein the photosensitizer is coupled to the binding protein via O6-alkylguanine-DNA alkyltransferase (hAGTm), a modified human DNA repair protein.
Claims22
A compound comprising:
- a photosensitizer covalently coupled to
- a binding protein selected from the group consisting of an antibody or its antigen-binding fragment thereof;
- and
- wherein the binding protein binds a growth factor receptor,
- the photosensitizer is coupled to the binding protein via O6-alkylguanine-DNA alkyltransferase (hAGTm), a modified human DNA repair protein, and
- wherein the binding protein comprising the amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 3.
A compound comprising:
- a binding protein comprising the amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 3,
- wherein the binding protein binds a growth factor receptor, and
- wherein the binding protein is covalently coupled to a modified human DNA repair protein called O6-alkylguanine-DNA alkyltransferase (hAGTm).
A compound comprising:
- a photosensitizer covalently coupled to
- a binding protein comprising a protein encoded by a polynucleotide having the nucleotide sequence of SEQ ID NO:
- 5;
- wherein the binding protein binds a growth factor receptor, and
- wherein the photosensitizer is coupled to the binding protein via O6-alkylguanine-DNA alkyltransferase (hAGTm), a modified human DNA repair protein.
Dependencies are inferred from the claim text.