TLR5 ligands, therapeutic methods, and compositions related thereto
AssigneeEmory University
InventorsAndrew T. Gewirtz, Benyue Zhang
Life of this patent
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Abstract
The disclosure relates to antiviral therapeutic methods and related compositions. In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection by administering a pharmaceutical composition comprising a TLR5 ligand, such as a flagellin, to a subject in need thereof.
Claims16
A method of treating a viral infection comprising administering an isolated flagellin in an effective amount to activate TLR5 to subject that is diagnosed with, suspected of, or exhibiting symptoms of a viral infection wherein the isolated flagellin is administered in the absence of administering a viral vaccine comprising viral nucleic acid or viral antigen.
A pharmaceutical composition comprising an isolated flagellin and a second antiviral agent wherein the second antiviral agent is selected from abacavir, acyclovir, adefovir, amantadine, amprenavir, rintatolimod, umifenovir, atazanavir, boceprevir, cidofovir, combivir, darunavir, delavirdine, didanosine, docosanol, edoxudine, efavirenz, emtricitabine, enfuvirtide, entecavir, famciclovir, fomivirsen, fosamprenavir, foscarnet, fosfonet, ganciclovir, ibacitabine, imunovir, idoxuridine, imiquimod, indinavir, inosine, interferon type III, interferon type II, interferon type I, lamivudine, lopinavir, loviride, maraviroc, moroxydine, methisazone, nelfinavir, nevirapine, nexavir, oseltamivir, peginterferon alfa-2a, penciclovir, peramivir, pleconaril, podophyllotoxin, raltegravir, ribavirin, rimantadine, ritonavir, pyramidine, saquinavir, stavudine, tenofovir, tenofovir disoproxil, tipranavir, trifluridine, tromantadine, valaciclovir, valganciclovir, vicriviroc, vidarabine, viramidine zalcitabine, zanamivir, and zidovudine.
A pharmaceutical composition comprising an isolated flagellin and efavirenz, emtricitabine, and tenofovir disoproxil.
A pharmaceutical composition comprising an isolated flagellin and abacavir, lamivudine, and zidovudine.
A pharmaceutical composition comprising an isolated flagellin and emtricitabine and tenofovir disoproxil.
Dependencies are inferred from the claim text.