Aurantiamide dipeptide derivatives for treatment or prevention of angiogenesis-related diseases
AssigneesMackay Medical College, Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital, Chang Gung University
InventorsHung-I Yeh, Shih-Wei Wang, Ching-Hu Chung, Pei-Wen Hsieh
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Abstract
The invention relates to a use of an aurantiamide dipepetide derivative in the treatment or prevention of angiogenesis-related diseases. Accordingly, aurantiamide dipeptide derivatives can be used as angiogenesis inhibitor, whereby preventing or treating invasive and metastatic cancer and ocular neovascularization (particularly macular degeneration such as pathological neovascularization of age-related macular degeneration (AMD)).
Claims10
A method for ameliorating or treating ocular neovascularization, comprising administering an effective amount of a compound of the following Formula (I) to a subject,
- wherein R is —(CH2)1-4phenyl wherein phenyl is unsubstituted or substituted by one to three hydroxyl, NH2, NO2 or alkyl;
- —(CH2)1-4indolyl;
- —(CH2)1-4naphthalenyl;
- or isopropyl,
- or a tautomer, stereoisomer or enantiomer thereof, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.