Pharmaceutical composition for use in the treatment and/or the prevention of osteoarticular diseases
AssigneeBone Therapeutics S.A.
InventorsEnrico Bastianelli, Pierre Attali, Chris Vervaet
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Abstract
An intra-articular pharmaceutical composition is used for the treatment and/or the prevention of acute or chronic osteoarticular diseases and acute or chronic osteoarticular symptoms especially osteoarthritis. The composition includes a possibly adequate pharmaceutical carrier or diluent, a glycosaminoglycan, a compound activating the alpha 2 adrenergic receptor, an anti-inflammatory agent and stem cells.
Claims9
A method for treating an osteoarticular disease in a mammalian subject, the method comprising intra-articularly injecting in a joint of the subject in need thereof a pharmaceutical composition comprising:
- an effective amount of hyaluronic acid or a derivative thereof;
- and
- an effective amount of α2 adrenergic receptor agonist compound, the α2 adrenergic receptor agonist compound comprising clonidine or p-aminoclonidine;
- wherein the pharmaceutical composition synergistically reduces joint degeneration by providing a decrease in articular accumulation of liquid and inflammation, synergistically reduces joint pain and/or synergistically improves joint mobility and function for two weeks or more.
Dependencies are inferred from the claim text.