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US 9,872,866 B2Granted
Vitamin D receptor/SMAD genomic circuit gates fibrotic response
AssigneesThe Salk Institute for Biological Studies, The University of Sydney
InventorsNing Ding, Michael Downes, Christopher Liddle, Ronald M. Evans
Life of this patent
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Abstract
The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
Claims5
A method for treating pancreatic fibrosis in a subject, comprising:
- administering to the subject a therapeutically effective amount of a composition comprising
- a nanoparticle comprising retinyl palmitate on its surface, and
- calcipotriol, which is in or attached to the nanoparticle,
- thereby treating the pancreatic fibrosis in the subject.
1 more element
Dependencies are inferred from the claim text.