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AssigneeThe Florida International University Board of Trustees
InventorsUpal Roy, Hong Ding, Madhavan Nair
Estimating the term…
The present invention provides novel, long-acting nanoformulated drugs and targeted drug delivery methods, and uses thereof. In one embodiment, the nanoformulated drug is a retroviral drug. In one embodiment, the nanoformulated composition comprises a nanocarrier with one or more incorporated drugs. In an exemplary embodiment, the drug is efavirenz (EFV). In a further embodiment, the nanocarrier is associated with an agent for targeting microfold cells (M-cells). In a specific embodiment, the targeting agent binds to an M-cell marker known as glycoprotein 2 (GP2). Via this mechanism, the nanodrug is targeted toward GALT.
A pharmaceutical composition comprising a nanodrug that comprises an active agent, a poloxamer, and an antibody to glycoprotein-2 (GP2) or antibody fragment to GP2 that targets microfold cells (M-cells) and facilitates the uptake of the nanodrug by M-cells.
A method of delivering an active agent to gut-associated lymphoid tissue (GALT) comprising administering, to a subject, a pharmaceutical composition comprising a nanodrug that comprises an active agent, a poloxamer, and an antibody to GP2 or antibody fragment to GP2 that targets M-cells and facilitates the uptake of the nanodrug by M-cells.
A pharmaceutical composition comprising a nanodrug comprising efavirenz and F127COOH conjugated to anti-GP2 antibody that facilitates the uptake of the nanodrug by M-cells, and wherein the nanodrug is coated with an enteric coating that degrades only at a pH above 5.0.
A method of delivering an active agent to gut-associated lymphoid tissue (GALT) comprising administering, to a subject, a pharmaceutical composition comprising a nanodrug comprising a F127COOH micelle conjugated to anti-GP2 antibody that facilitates the uptake of the F127COOH micelle by M-cells, and further comprising efavirenz encapsulated in the F127COOH micelle, characterized in that the nanodrug is coated with an enteric coating that degrades only at a pH above 5.0.
Dependencies are inferred from the claim text.