Methods of using propentofylline to treat glioma and glioblastoma
AssigneesThe Translational Genomics Research Institutet, Mayo Foundation for Medical Education and Research
InventorsNhan Tran, Joseph C. Loftus, Harshil Dhruv
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Abstract
The invention encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting TROY to treat the patient with cancer.
Claims16
A method of sensitizing a patient with glioma to radiation therapy and/or chemotherapy, the method comprising
- administering to the patient with glioma propentofylline or a pharmaceutically acceptable salt thereof in an amount sufficient to inhibit TROY expression, but the amount is less than sufficient to substantially reduce viability of glioma cells.
A method of sensitizing glioblastoma cells in a subject, the method comprising the steps of contacting the glioblastoma cells with a therapeutically effective amount of propentofylline or a pharmaceutically acceptable salt thereof in an amount sufficient to inhibit TROY expression, but the amount is less than sufficient to substantially reduce viability of glioblastoma cells, and further contacting the glioblastoma cells with another pharmaceutical composition.
Dependencies are inferred from the claim text.