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US 9,872,856 B2Granted
Systems and methods for treating an opioid-induced adverse pharmacodynamic response
AssigneePurdue Pharma L.P.
InventorsMichele Hummel, Donald J. Kyle, Garth Whiteside
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Abstract
Disclosed in certain embodiments is a method of treating or preventing an opioid-induced adverse pharmacodynamic response comprising administering to a patient in need thereof an effective amount of buprenorphine.
Claims28
A pharmaceutical unit dosage form comprising:
- (a) an effective amount of an opioid other than buprenorphine to treat pain;
- (b) an effective amount of buprenorphine to prevent or treat an opioid-induced adverse pharmacodynamic response that does not affect the analgesic effectiveness of the opioid;
- and
- (c) a pharmaceutically acceptable excipient;
- wherein the dosage form provides a plasma level of buprenorphine of about 1 ng/ml or less after administration to a human patient.
2 more elements
A kit comprising:
- (i) a unit dosage form comprising an opioid other than buprenorphine, in an effective amount to treat pain;
- and
- (ii) a unit dosage form comprising an effective amount of buprenorphine to prevent or treat an opioid-induced adverse pharmacodynamics response that does not affect the analgesic effectiveness of the opioid;
- wherein the unit dosage form comprising buprenorphine provides a plasma level of buprenorphine of about 1 ng/ml or less after administration to a human patient.
1 more element
Dependencies are inferred from the claim text.