Multiparticles safeguarded against ethanolic dose-dumping

An oral pharmaceutical dosage form comprising a pharmacologically active ingredient embedded in a matrix material, wherein:

• the pharmacologically active ingredient is one selected from pharmacologically active ingredients classified in Anatomical Therapeutic Chemical Classification System (ATC), class Nervous System;
• the matrix material comprises a mixture of an alkyl cellulose and a heteropolysaccharide;
• the alkyl cellulose is present in the dosage form in an amount of at least 50 wt.-% relative to the total weight of the dosage form;
• the heteropolysaccharide is present in the dosage form in an amount of below 50 wt.-% relative to the total weight of the dosage form;
• the total content of alkyl cellulose and heteropolysaccharide is at least 60 wt.-% relative to the total weight of the dosage form;
• the pharmaceutical dosage form releases by 60 minutes more than 60% of the pharmacologically active ingredient when release of the pharmacologically active ingredient from the pharmaceutical dosage form is measured with a paddle apparatus at 50 rpm, at 37±5° C., in 900 mL 0.1 M HCl (pH 1.0) or simulated intestinal fluid at pH 6.8 (phosphate buffer) or pH 4.5;
• and
• the pharmaceutical dosage form provides resistance against dose dumping in aqueous ethanol.