Pharmaceutical composition of oxidised avidin suitable for inhalation
AssigneeAlfasigma S.P.A.
InventorRita De Santis
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Abstract
The present invention describes oxidized avidin, suitable for inhalation, for conditioning the lung affected by inoperable/diffuse diseases, enabling the targeted delivery of biotinylated therapeutic agents to it.
Claims6
A method for treating a lung cancer disease comprising:
- administering to a patient in need thereof an effective amount of oxidized avidin via nebulization and inhalation of a pharmaceutical inhalable formulation comprising oxidized avidin, a sterile buffer solution comprising sodium acetate at pH of from 5.0 to 6.9, and a non-ionic agent selected from the group consisting of mannitol, glycerol, glucose, lactose, trehalose, sucrose, propylene-glycol, sorbitol, xylitol, polyethylene-glycol, ethanol and isopropanol, wherein the oxidized avidin is at a concentration of from 0.005% to about 0.5% (w/v), and thereafter
- administering to the patient a biotinylated therapeutic agent selected from the group consisting of radioactive agents, monoclonal antibodies, cytokines, chemokines, enzymes, chemotherapeutics, viral or plasmid vectors and cells.
A kit comprising a pharmaceutical inhalable formulation contained in a nebulizer and comprising oxidized avidin, a sterile buffer solution comprising sodium acetate at pH of from 5.0 to 6.9, and a non-ionic agent selected from the group consisting of mannitol, glycerol, glucose, lactose, trehalose, sucrose, propylene-glycol, sorbitol, xylitol, polyethylene-glycol, ethanol, and isopropanol, wherein the oxidized avidin is at a concentration of from 0.005% to about 0.5% (w/v).
Dependencies are inferred from the claim text.