Core sheath drug delivery devices

A device comprising:

• (a) a core, said core comprising at least 90% of polyurethane,
• wherein the polyurethane is selected from aliphatic polyether-based thermoplastic polyurethanes, aliphatic hydrophilic polyether-based thermoplastic polyurethanes, aromatic polyether-based thermoplastic polyurethanes, aliphatic polycarbonate-based thermoplastic polyurethanes, aromatic polycarbonate-based thermoplastic polyurethanes, aromatic polyether based polyurethane elastomers, thermoplastic polyether poly(urethanes), thermoplastic silicone polyether polyurethanes, thermoplastic silicone polycarbonate polyurethanes and hydrophilic thermoplastic polyurethane elastomers;
• (b) a sheath, said sheath substantially or completely surrounding said core, said sheath comprising from 50 to 100% of ethylene vinyl acetate copolymer,
• wherein the ethylene vinyl acetate copolymer has a vinyl acetate content from 1 to 50% w/w, and,
• wherein said sheath has a thickness from 5 to 500 μm;
• and
• (c) one or more active pharmaceutical ingredients dissolved or dispersed in said core and/or said sheath;
• wherein the one or more active pharmaceutical ingredients are eluted at or near zero order.