US 9,872,825 B2Granted

Peptide with anti-aging effect and use thereof

AssigneeOsaka University

InventorsHironori Nakagami, Ryuichi Morishita, Hideki Tomioka, Akiko Tenma

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Abstract

An object of the present invention to discover a short peptide having an anti-aging effect and to provide a novel anti-aging agent comprising the peptide as an active ingredient. The inventors have discovered that a peptide consisting of an amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO: 1) or a partial sequence thereof and having one or more effects selected from the group consisting of promoting fibroblast growth, promoting hyaluronic acid production and contracting a collagen gel, or a derivative or salt of the peptide is useful as an active ingredient of an anti-aging agent.

Claims23

Dependent claims

A peptide consisting of the amino acid sequence ELKLIFLHRLKRLRKRLKRK (SEQ ID NO:

1), or a derivative or salt of the peptide,
wherein the derivative has a modification selected from C-terminal amidation or esterification, protection of an N-terminal amino group with a protecting group, protection of a substituent on an amino acid side chain in the molecule with a protecting group, a combination of C-terminal amidation or esterification and protection of an N-terminal amino group with a protecting group, a combination of C-terminal amidation or esterification and protection of a substituent on an amino acid side chain in the molecule with a protecting group, a combination of protection of an N-terminal amino group with a protecting group and protection of a substituent on an amino acid side chain in the molecule with a protecting group, and a combination of C-terminal amidation or esterification, protection of an N-terminal amino group with a protecting group and protection of a substituent on an amino acid side chain in the molecule with a protecting group.

Dependencies are inferred from the claim text.

Facts

Application: 14/780,122Filed 27 Mar 2014
Priority: JP 2013-07179129 Mar 2013
Published: US 2016/0101032 A114 Apr 2016
Granted: 23 Jan 2018
Term ends: Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61K 8/64
Containing organic compounds: proteins; Peptides; Derivatives or degradation products thereof
A23L 33/18
Amino acids, peptides or proteins: peptides; Protein hydrolysates
A61K 38/10
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: peptides having 12 to 20 amino acids
A61P 17/00
Drugs for dermatological disorders

Family

US 2016/0101032 A1Pre-grant publication · published 14 Apr 2016
US 9,872,825 B2This patent

From the US filing history. Foreign family members aren’t listed.

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