Energy delivery systems and uses thereof

A method of treating a peripheral lung tissue region in a subject, comprising

• steering a microwave energy delivery device through the subject's lung and positioning the microwave energy delivery device at a target peripheral lung tissue region, and ablating the target peripheral lung tissue region with energy from the microwave energy delivery device,
• wherein the steering is through the subject's mouth, through the subject's trachea, and through the subject's lung,
• wherein the microwave energy delivery device is of sufficient length to extend from the mouth of a human subject, through the trachea of the human subject, into the lung of the human subject and to the peripheral lung of the human subject;
• wherein the diameter of the microwave energy delivery device is approximately 2 mm or less;
• wherein the microwave energy delivery device is flexible;
• wherein the microwave energy delivery device comprises an inner conductor, an outer conductor, and a stylet tip,
• the inner conductor is a conductor of microwave energy,
• the outer conductor is a conductor of microwave energy,
• the inner conductor having a proximal end and a distal end,
• the outer conductor having a proximal end and a distal end,
• the stylet tip having a proximal end and a distal end,
• the stylet tip attached at the distal end of the microwave energy delivery device;
• wherein the microwave energy delivery device has therein one or more coolant channels for circulating and recirculating coolant, wherein the one or more coolant channels does not extend to the distal end of the stylet tip;
• wherein the microwave energy delivery device has thereon a temperature sensor.