A collection bag for use in a procedure on a biologic structure in a cavity in a patient to entrap biologic material produced by the procedure, said bag being configured to be introduced through a port into the patient and comprising a body formed of a flexible sheet material, said body having a hollow interior, a top portion including a first mouth located thereat and a second portion projecting outward from said top portion, said second portion having a second mouth thereat, said first mouth being openable to enable the biologic structure to be introduced therethrough into said hollow interior and to enable an instrument to be introduced therethrough to engage the biologic structure to effect a procedure on the biologic structure, said second mouth being openable to enable a viewing instrument to be extended therethrough into said hollow interior to enable the visualization of the engagement of the biologic structure by the instrument, said second mouth comprising a closure and a first portion of a draw-string coupled to said closure, said closure being initially open to enable the viewing instrument to be inserted through said second mouth and removed from said second mouth, said first portion of said draw-string being configured to be pulled to close said closure after the viewing instrument has been removed from said second mouth to thereby entrap the biologic material produced by the procedure within said hollow interior, whereupon said collection bag may be withdrawn from the body of the patient through the port.