Sensors for continuous analyte monitoring, and related methods

A sensor device for measuring analyte concentration in a host, comprising:

• an in vivo portion configured for insertion under a host's skin, wherein the in vivo portion comprises at least one sensor, a bioactive agent, a biodegradable material, a hardening agent, and a membrane, wherein the hardening agent is integrated into the membrane, wherein the membrane covers at least a portion of the at least one sensor, wherein the hardening agent increases a column strength of the sensor, wherein the biodegradable material encapsulates at least a portion of the sensor, wherein the biodegradable material is configured to biodegrade following insertion into the host, wherein the biodegradable material is formed of a material that provides the sensor with sufficient column strength to prevent sensor buckling during insertion of the in vivo portion, wherein the biodegradable material has a Rockwell Hardness of 25 D to 65 D, wherein the at least one sensor lacks a column strength necessary to be inserted alone through the host's skin without buckling, wherein the bioactive agent is configured to suppress wounding;
• and
• an ex vivo portion configured to remain above the host's skin surface after insertion of the in vivo portion, wherein the ex vivo portion is configured to receive pressure from a user to cause insertion of the in vivo portion of the sensor device, wherein the ex vivo portion comprises an adhesive configured to adhere the ex vivo portion to the host's skin.