Human placental collagen compositions, and methods of making and using the same
AssigneeCelularity Inc.
InventorsMohit Bhatia, Chris Lugo, Qian Ye, James W. Edinger
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.
Claims18
A composition comprising placental extracellular matrix, wherein said composition comprises at least 80% collagen by dry weight, wherein said collagen comprises (i) between 74% and 90% Type I collagen, between 4% to 6% Type III collagen, and between 2% to 15% type IV collagen, (ii) no detectable amounts of fibronectin or laminin, and (iii) additional extracellular matrix components selected from the following groups:
- (a) 4.7% elastin by dry weight and 0.28% glycosaminoglycans by dry weight;
- (b) 3.2% elastin by dry weight and 0.34% glycosaminoglycans by dry weight;
- (c) 4.4% elastin by dry weight and 0.38% glycosaminoglycans by dry weight;
- and
- (d) 3.5% elastin by dry weight and 0.59% glycosaminoglycans by dry weight.
Dependencies are inferred from the claim text.