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US 9,757,041 B2Granted
Hemodynamic reserve monitor and hemodialysis control
AssigneesFlashback Technologies, Inc., The Regents of the University of Colorado, a body corporate
InventorsGregory Zlatko Grudic, Steven Lee Moulton, Isobel Jane Mulligan
Life of this patent
Estimating the term…
Abstract
Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the future. Tools and techniques for estimating and/or predicting a patient's dehydration state. Tools and techniques for controlling a hemodialysis machine based on the patient's estimated and/or predicted hemodynamic reserve index.
Claims57
A system, comprising:
- one or more sensors to obtain physiological data from a patient;
- and
- a computer system in communication with the one or more sensors, the computer system comprising:
- one or more processors;
- and
- a computer readable medium in communication with the one or more processors, the computer readable medium having encoded thereon a set of instructions executable by the computer system to perform one or more operations, the set of instructions comprising:
- instructions for receiving the physiological data from the one or more sensors, wherein the physiological data comprises waveform data;
- instructions for analyzing the physiological data;
- instructions for estimating a hemodynamic reserve index of the patient, based on analysis of the physiological data, by comparing the physiological data to a model constructed using the following formula:
- HDRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where HDRI(t) is the hemodynamic reserve at time t, BLV(t) is an intravascular volume loss of a test subject at time t, and BLVHDD is an intravascular volume loss at a point of hemodynamic decompensation of the test subject, and wherein the instructions for estimating the hemodynamic reserve index comprise:
- instructions for comparing the waveform data with a plurality of sample waveforms, each of the sample waveforms corresponding to a different value of the hemodynamic reserve index, to produce a similarity coefficient expressing a similarity between the waveform data and each of the sample waveforms;
- instructions for normalizing the similarity coefficients for each of the sample waveforms;
- and
- instructions for summing the normalized similarity coefficients to produce an estimated hemodynamic reserve index value for the patient;
- and
- instructions for displaying, on a display device, an estimate of the hemodynamic reserve index of the patient.
28 more elements
A method, comprising:
- monitoring, with one or more sensors, physiological data of a patient, wherein the physiological data comprises waveform data;
- analyzing, with a computer system, the physiological data;
- estimating, with the computer system, a hemodynamic reserve index of the patient, based on analysis of the physiological data, by comparing the physiological data to a model constructed using the following formula:
- HDRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where HDRI(t) is the hemodynamic reserve at time t, BLV(t) is an intravascular volume loss of a test subject at time t, and BLVHDD is an intravascular volume loss at a point of hemodynamic decompensation of the test subject, and wherein estimating the hemodynamic reserve index comprises:
- comparing the waveform data with a plurality of sample waveforms, each of the sample waveforms corresponding to a different value of the hemodynamic reserve index, to produce a similarity coefficient expressing a similarity between the waveform data and each of the sample waveforms;
- normalizing the similarity coefficients for each of the sample waveforms;
- and
- summing the normalized similarity coefficients to produce an estimated hemodynamic reserve index value for the patient;
- and
- displaying, with a display device, an estimate of the hemodynamic reserve index of the patient.
22 more elements
An apparatus, comprising:
- a computer readable medium having encoded thereon a set of instructions executable by one or more computers to perform one or more operations, the set of instructions comprising:
- instructions for receiving physiological data from one or more sensors, wherein the physiological data comprises waveform data;
- instructions for analyzing the physiological data;
- instructions for estimating a hemodynamic reserve index of the patient, based on analysis of the physiological data, by comparing the physiological data to a model constructed using the following formula:
- HDRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where HDRI(t) is the hemodynamic reserve at time t, BLV(t) is an intravascular volume loss of a test subject at time t, and BLVHDD is an intravascular volume loss at a point of hemodynamic decompensation of the test subject, and wherein the instructions for estimating the hemodynamic reserve index comprise:
- instructions for comparing the waveform data with a plurality of sample waveforms, each of the sample waveforms corresponding to a different value of the hemodynamic reserve index, to produce a similarity coefficient expressing a similarity between the waveform data and each of the sample waveforms;
- instructions for normalizing the similarity coefficients for each of the sample waveforms;
- and
- instructions for summing the normalized similarity coefficients to produce an estimated hemodynamic reserve index value for the patient;
- and
- instructions for displaying, on a display device, an estimate of the hemodynamic reserve index of the patient.
23 more elements
A method, comprising:
- monitoring, with one or more sensors, physiological data of a patient, wherein the physiological data comprises waveform data;
- analyzing, with a computer system, the physiological data;
- estimating, with the computer system, a dehydration state of the patient from a hemodynamic reserve index of the patient, based on analysis of the physiological data, by comparing the physiological data to a model constructed using the following formula:
- HDRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where HDRI(t) is the hemodynamic reserve at time t, BLV(t) is an intravascular volume loss of a test subject at time t, and BLVHDD is an intravascular volume loss at a point of hemodynamic decompensation of the test subject, and wherein estimating the dehydration state comprises:
- comparing the waveform data with a plurality of sample waveforms, each of the sample waveforms corresponding to a different value of the hemodynamic reserve index, to produce a similarity coefficient expressing a similarity between the waveform data and each of the sample waveforms;
- normalizing the similarity coefficients for each of the sample waveforms;
- and
- summing the normalized similarity coefficients to produce an estimated hemodynamic reserve index value for the patient;
- and
- displaying, on a display device, an estimate of the dehydration state of the patient.
22 more elements
A method, comprising:
- monitoring, with one or more sensors, physiological data of a patient, wherein the physiological data comprises waveform data;
- analyzing, with a computer system, the physiological data;
- estimating, with the computer system, a hemodynamic reserve index of the patient, based on analysis of the physiological data, by comparing the physiological data to a model constructed using the following formula:
- HDRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where HDRI(t) is the hemodynamic reserve at time t, BLV(t) is an intravascular volume loss of a test subject at time t, and BLVHDD is an intravascular volume loss at a point of hemodynamic decompensation of the test subject, and wherein estimating the hemodynamic reserve index comprises:
- comparing the waveform data with a plurality of sample waveforms, each of the sample waveforms corresponding to a different value of the hemodynamic reserve index, to produce a similarity coefficient expressing a similarity between the waveform data and each of the sample waveforms;
- normalizing the similarity coefficients for each of the sample waveforms;
- and
- summing the normalized similarity coefficients to produce an estimated hemodynamic reserve index value for the patient;
- displaying, with a display device, an estimate of the hemodynamic reserve index of the patient;
- and
- controlling operation of hemodialysis equipment based on the estimated hemodynamic reserve index.
23 more elements
A system, comprising:
- a hemodialysis machine;
- one or more sensors to obtain physiological data from a patient;
- and
- a computer system in communication with the one or more sensors and the hemodialysis machine, the computer system comprising:
- one or more processors;
- and
- a computer readable medium in communication with the one or more processors, the computer readable medium having encoded thereon a set of instructions executable by the computer system to perform one or more operations, the set of instructions comprising:
- instructions for receiving the physiological data from the one or more sensors, wherein the physiological data comprises waveform data;
- instructions for analyzing the physiological data;
- instructions for estimating a hemodynamic reserve index of the patient, based on analysis of the physiological data, by comparing the physiological data to a model constructed using the following formula:
- HDRI
-
- (
- t
- )
- =
- 1
- -
- BLV
-
- (
- t
- )
- BLV
- HDD
- where HDRI(t) is the hemodynamic reserve at time t, BLV(t) is an intravascular volume loss of a test subject at time t, and BLVHDD is an intravascular volume loss at a point of hemodynamic decompensation of the test subject, and wherein the instructions for estimating the hemodynamic reserve index comprise:
- instructions for comparing the waveform data with a plurality of sample waveforms, each of the sample waveforms corresponding to a different value of the hemodynamic reserve index to produce a similarity coefficient expressing a similarity between the waveform data and each of the sample waveforms;
- instructions for normalizing the similarity coefficients for each of the sample waveforms;
- and
- instructions for summing the normalized similarity coefficients to produce an estimated hemodynamic reserve index value for the patient;
- and
- instructions for controlling operation of hemodialysis machine based on the estimated hemodynamic reserve index.
29 more elements
Dependencies are inferred from the claim text.