Dosimetric method
AssigneeNitto Denko Corporation
InventorsGeofrey De Visscher, Nicolas Schüwer
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Abstract
The present invention relates to a method for detecting and optionally quantifying exposure to ionizing radiation and applications thereof. More particularly, the invention relates to the detection and/or quantification of ionizing radiation exposure by detecting the colour change of one or more dianhydrohexitol compounds, such as isosorbide, caused by ionizing radiation. It also relates to the use of dianhydrohexitol compounds for detecting exposure to irradiation, to a system and kit that may be used for such purposes, and to a method for making sterilized objects, which also relies on the colour change induced by ionizing radiation.
Claims20
A method for detecting and optionally quantifying exposure to ionizing radiation, comprising the steps:
- (a) providing a dianhydrohexitol or dianhydrohexitol-containing composition, wherein the dianhydrohexitol is one or more of isosorbide, isomannide and isoidide;
- (b) exposing the dianhydrohexitol or dianhydrohexitol-containing composition to ionizing radiation, thereby effecting a colour change in the dianhydrohexitol;
- (c) detecting the colour change in the dianhydrohexitol or dianhydrohexitol-containing composition;
- and optionally
- (d) quantifying the dose of ionizing radiation absorbed by the dianhydrohexitol or dianhydrohexitol-containing composition on the basis of the colour change.
A method for detecting and optionally quantifying exposure to ionizing radiation, comprising the steps:
- (a) providing a dianhydrohexitol or dianhydrohexitol-containing composition, wherein the dianhydrohexitol is one or more of isosorbide, isomannide and isoidide;
- (b) exposing the dianhydrohexitol or dianhydrohexitol-containing composition to ionizing radiation, thereby producing a free radical;
- (c) detecting a free radical in the dianhydrohexitol or dianhydrohexitol-containing composition by electron paramagnetic resonance (EPR);
- and optionally
- (d) quantifying the dose of ionizing radiation absorbed by the dianhydrohexitol or dianhydrohexitol-containing composition on the basis of the EPR signal.
A system for detecting and optionally quantifying exposure to ionizing radiation comprising:
- a dianhydrohexitol;
- and
- a means to determine if (i) the dianhydrohexitol has been exposed to a pre-defined dose of ionizing radiation and optionally (ii) the quantity of the exposure that has occurred.
A kit comprising:
- a dianhydrohexitol or dianhydrohexitol-containing composition, wherein the dianhydrohexitol is one or more of isosorbide, isomannide and isoidide;
- and
- a means to determine if (i) the dianhydrohexitol or dianhydrohexitol-containing composition has been exposed to a pre-defined dose of ionizing radiation and optionally (ii) the quantity of the exposure that has occurred.
Dependencies are inferred from the claim text.