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US 9,752,195 B2Granted
TTC8 as prognostic gene for progressive retinal atrophy in dogs
AssigneeAnimal Health Trust
InventorsCathryn Suzanne Mellersh, Louise Mary Downs
Life of this patent
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Abstract
The invention relates to the use of the TTC8 gene as a biomarker for the prognosis of a canine mammal developing progressive retinal atrophy. The invention also relates to in vitro methods of prognosing progressive retinal atrophy in a canine mammal by detecting a genetic variation within the TTC8 gene and to primers and prognostic kits for use in said method.
Claims7
A method comprising:
- assessing a canine mammal for the presence or absence of a single base deletion in TTC8 gene at position 63,129154 on chromosome 8 (CanFam 2.0) by obtaining a sample comprising a nucleic acid from the canine mammal and
- detecting the presence or absence of the single base deletion by amplifying a part of the TTC8 gene using a forward primer comprising SEQ ID NO:1 and a reverse primer comprising SEQ ID NO:2,
- wherein the canine mammal is a Golden Retriever.
Dependencies are inferred from the claim text.